Publikationer från Malmö universitet
Endre søk
Begrens søket
1 - 14 of 14
RefereraExporteraLink til resultatlisten
Permanent link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Treff pr side
  • 5
  • 10
  • 20
  • 50
  • 100
  • 250
Sortering
  • Standard (Relevans)
  • Forfatter A-Ø
  • Forfatter Ø-A
  • Tittel A-Ø
  • Tittel Ø-A
  • Type publikasjon A-Ø
  • Type publikasjon Ø-A
  • Eldste først
  • Nyeste først
  • Skapad (Eldste først)
  • Skapad (Nyeste først)
  • Senast uppdaterad (Eldste først)
  • Senast uppdaterad (Nyeste først)
  • Disputationsdatum (tidligste først)
  • Disputationsdatum (siste først)
  • Standard (Relevans)
  • Forfatter A-Ø
  • Forfatter Ø-A
  • Tittel A-Ø
  • Tittel Ø-A
  • Type publikasjon A-Ø
  • Type publikasjon Ø-A
  • Eldste først
  • Nyeste først
  • Skapad (Eldste først)
  • Skapad (Nyeste først)
  • Senast uppdaterad (Eldste først)
  • Senast uppdaterad (Nyeste først)
  • Disputationsdatum (tidligste først)
  • Disputationsdatum (siste først)
Merk
Maxantalet träffar du kan exportera från sökgränssnittet är 250. Vid större uttag använd dig av utsökningar.
  • 1. Anderson, M
    et al.
    Stecksen-Blicks, Christina
    Malmö högskola, Odontologiska fakulteten (OD).
    Stenlund, Hans
    Ranggard, L
    Tsilingaridis, Georgios
    Mejàre, Ingegerd
    Malmö högskola, Odontologiska fakulteten (OD).
    Detection of Approximal Caries in 5-year-old Swedish Children2005Inngår i: Caries Research, ISSN 0008-6568, E-ISSN 1421-976X, Vol. 39, nr 2, s. 92-99Artikkel i tidsskrift (Annet vitenskapelig)
    Abstract [en]

    The aim was to assess how accurately some commonly used risk factors/risk markers (predictors) for caries development could identify children with and without approximal caries as judged from bitewing radiography. Two hundred and sixtyseven consecutive 5-year-old children from two Swedish cities participated. Three experienced dentists examined the children. The predictors were the overall dmfs (de-cayed, missing and filled surfaces) value (canines and molars), the number of occlusal dmfs, the frequency of intake of between-meal sugary products, visible plaque on free smooth surfaces of second primary molars, toothbrushing habits and (before bitewing examination) an overall judgement by the examining dentist. The mean dmfs value without bitewing examination was 0.40 (SD = 1.22). Twelve percent of the children had at least one dentin lesion and 33% at least one enamel lesion that were detected from bitewing examination only. The gain from adding bitewing examination to clinical examination amounted to a mean of 1.2 approximal enamel and/or dentin lesions. The ability to correctly identify children with approximal caries from the predictors was limited; sensitivity ranged from 0.27 to 0.75 and specificity ranged from 0.41 to 0.93. The single best predictor was the dentist's overall judgement with an average precision of 73%; average sensitivity for the presence of enamel and dentin lesions was 0.48 and for the presence of dentin lesions 0.66. The rest of the predictors added little to the predictive power. It is concluded that 33% of the 5-year-olds, representing a low caries prevalence population, benefited from bitewing examination. The ability to identify these children from the predictors was, however, limited. Copyright (c) 2005 S. Karger AG, Basel.

  • 2.
    Ashi, H
    et al.
    Department of Cariology, Institute of Odontology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
    Lara-Capi, C
    Department of Surgery, Microsurgery and Medicine, School of Dentistry, University of Sassari, Italy.
    Campus, G
    Department of Surgery, Microsurgery and Medicine, School of Dentistry, University of Sassari, Italy; WHO Collaborating Centre for Epidemiology and Preventive Dentistry, Milan, Italy.
    Klingberg, Gunilla
    Malmö högskola, Odontologiska fakulteten (OD).
    Lingström, Peter
    Department of Cariology, Institute of Odontology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SE-405 30, Sweden; WHO Collaborating Centre for Epidemiology and Preventive Dentistry, Milan, Italy.
    Sweet Taste Perception and Dental Caries in 13- to 15-Year-Olds: A Multicenter2017Inngår i: Caries Research, ISSN 0008-6568, E-ISSN 1421-976X, Vol. 51, nr 4, s. 443-450Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Dietary habits and, in particular, the intake frequency of sucrose are of major importance for the development of dental caries. The perception of sweet taste is believed to have an influence on sucrose intake and therefore affects the predisposition to dental caries. The aim was to study the caries experience and sweet taste perception and to further analyze the possible relationship between the 2 tested variables in 13- to 15-year-old children from 3 different geographical areas. A cross-sectional survey comprising 669 children (220 Italian, 224 Mexican, and 225 Saudi Arabian) was conducted. The children were examined in their school setting. A sweet taste perception level was determined by the sweet taste threshold (TT) and sweet taste preference (TP). The sweet test was performed with sucrose solutions varying in concentration from 1.63 to 821.52 g/L. The International Caries Detection and Assessment System (ICDAS) and DMFS indices were used to diagnose caries. The highest mean value for TT was found for Italian children followed by Saudi and Mexican. Saudi schoolchildren showed the highest mean values for TP and DMFS, followed by Italian and Mexican. A statistically significant difference for TP, TT, DMFS, and initial caries was found between the 3 countries. A weak yet positive correlation was found between taste perception (TT and TP) versus DMFS and manifest caries in all 3 countries (r = 0.137-0.313). The findings of the present study showed a variation in sweet taste perception between the 3 countries, which may influence the caries outcome of the children in the individual countries.

  • 3.
    Astvaldsdottir, Alfheiour
    et al.
    Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden.
    Naimi-Akbar, Aron
    Department of Dental Medicine, Karolinska Institutet, PO Box 4064, Huddinge, SE-14104, Sweden; Department of Oral and Maxillofacial Surgery, Karolinska University Hospital, Huddinge, Sweden.
    Davidson, Thomas
    Division of Health Care Analysis, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
    Brolund, Agneta
    Swedish Agency for Health Technology Assessment and Assessment of Social Services (SBU), Stockholm, Sweden.
    Lintamo, Laura
    Swedish Agency for Health Technology Assessment and Assessment of Social Services (SBU), Stockholm, Sweden.
    Granath, Anna Attergren
    Swedish Agency for Health Technology Assessment and Assessment of Social Services (SBU), Stockholm, Sweden.
    Tranæus, Sofia
    Malmö högskola, Odontologiska fakulteten (OD). Department of Dental Medicine, Karolinska Institutet, PO Box 4064, Huddinge, SE-14104, Sweden; Swedish Agency for Health Technology Assessment and Assessment of Social Services (SBU), Stockholm, Sweden.
    Östlund, Pernilla
    Malmö högskola, Odontologiska fakulteten (OD). Swedish Agency for Health Technology Assessment and Assessment of Social Services (SBU), Stockholm, Sweden.
    Arginine and Caries Prevention: A Systematic Review2016Inngår i: Caries Research, ISSN 0008-6568, E-ISSN 1421-976X, Vol. 50, nr 4, s. 383-393Artikkel, forskningsoversikt (Fagfellevurdert)
    Abstract [en]

    Objectives: To evaluate the available evidence that the use of arginine-containing dental care products prevents the development of new caries lesions and the progression of existing lesions. Search Methods: We performed a systematic literature search of databases including PubMed, the Cochrane Library and EMBASE. Selection Criteria: We selected randomized controlled trials of treatment with arginine in fluoride-containing dental products measuring dental caries incidence or progression in children, adults and elderly subjects. Data Collection and Analysis: Two review authors independently assessed trials for risk of bias and evaluated overall study quality using the GRADE classification. Main Results: Due to conflicts of interest and weak transferability to Swedish conditions, no conclusions can be drawn from studies on the effects of arginine-fluoride toothpaste in children. Arginine-containing toothpaste costs about 40% more than basic fluoride toothpaste; to determine whether it is more cost-effective, the higher cost must be considered in relation to any additional caries-preventive effect. The literature review also disclosed some questionable research ethics: in several of the studies, the children in the control group used non-fluoride toothpaste. Toothpaste without fluoride is not as effective against dental caries as the standard treatment - fluoride toothpaste - which has a well -documented effect. This contravenes the fundamental principles of research ethics. Conclusion: At present there is insufficient evidence in support of a caries-preventive effect for the inclusion of arginine in toothpastes. More rigorous studies, and studies which are less dependent on commercial interests, are required. (C) 2016 S. Karger AG, Basel

  • 4.
    Bikker, Floris J.
    et al.
    Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam (ACTA), Free University of Amsterdam and University of Amsterdam, Amsterdam, The Netherlands.
    Hoogenkamp, Michel A.
    Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam (ACTA), Free University of Amsterdam, University of Amsterdam, Amsterdam, Netherlands.
    Malhaoui, Amine
    Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam (ACTA), Free University of Amsterdam, University of Amsterdam, Gustav Mahlerlaan 3004, Amsterdam, NL-1081 LA, Netherlands; Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam (ACTA), Free University of Amsterdam, University of Amsterdam, Amsterdam, Netherlands.
    Nazmi, Kamran
    Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam (ACTA), Free University of Amsterdam, University of Amsterdam, Gustav Mahlerlaan 3004, Amsterdam, NL-1081 LA, Netherlands.
    Neilands, Jessica
    Malmö universitet, Odontologiska fakulteten (OD).
    Krom, Bastiaan P.
    Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam (ACTA), Free University of Amsterdam, University of Amsterdam, Amsterdam, Netherlands.
    Phytosphingosine Prevents the Formation of Young Salivary Biofilms in vitro2018Inngår i: Caries Research, ISSN 0008-6568, E-ISSN 1421-976X, Vol. 52, nr 1-2, s. 7-13Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Dental biofilms are formed in a multistep process that is initiated by the adhesion of oral bacteria to the dental hard surface. As dental biofilms are associated with oral diseases their control is necessary in order to maintain oral health. Recently, it was revealed that phytosphingosine (PHS)-treated hydroxyapatite discs showed anti-adhesive activity in a static in vitro biofilm model against Streptococcus mutans. The goal of the present study was to further unravel the anti-adhesive and anti-biofilm properties of PHS in both static and dynamic in vitro biofilm models against a full salivary inoculum. After 3 h under static conditions, bacterial adherence on PHS-treated cover glass slides was reduced by 60% compared to the untreated surface. After 6 and 24 h under static conditions, no significant differences in bacterial adherence were observed between PHS-treated and untreated cover glass slides. However, under dynamic conditions, i.e., the presence of shear forces, virtually no bacterial adherence was observed for up to 16 h on PHS-coated surfaces. Besides, PHS showed a strong bactericidal activity on salivary biofilms. Treatment of a 3- and 6-h statically grown biofilm resulted in a 99 and 94% reduction of viable cells, respectively, which was effectuated within minutes. In principle, these anti-adherence and anti-biofilm properties make PHS a promising candidate ingredient for use in oral care products aimed at oral microbial control. (C) 2017 S. Karger AG, Basel

  • 5.
    Hedenbjörk-Lager, Anders
    et al.
    Malmö högskola, Odontologiska fakulteten (OD).
    Bjørndal, Lars
    Gustafsson, Anders
    Sorsa, Timo
    Tjäderhane, Leo
    Åkerman, Sigvard
    Malmö högskola, Odontologiska fakulteten (OD).
    Ericson, Dan
    Malmö högskola, Odontologiska fakulteten (OD).
    Caries correlates strongly with salivary levels of Matrix Metalloproteinase-82015Inngår i: Caries Research, ISSN 0008-6568, E-ISSN 1421-976X, Vol. 49, nr 1, s. 1-8, artikkel-id 49Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The caries process in dentin involves the degradation of both mineral and organic matrix. The demineralization has been demonstrated to be caused by bacterial acids. How-ever, the collagen degradation is considered to be initiated by endogenous proteolytic enzymes, mainly collagenolytic matrix metalloproteinases (MMPs). This paper aims to relate salivary MMP-8 (or salivary collagenase-2) and tissue inhibi-tor of MMP (TIMP-1) levels to manifest caries in a large num-ber of subjects. A random sample of 451 adults (aged 18-87 years) living in the south of Sweden was included in this study. Standard clinical examinations were performed, and stimulated saliva was collected and analyzed for concentra-tions of MMP-8, TIMP-1 and total protein, using an immuno-fluorometric assay, an enzyme-linked immunosorbent assay and the Bradford assay, respectively. Salivary numbers of mutans streptococci and lactobacilli were determined using a chair-side kit. Subjects with manifest caries lesions present-ed with elevated levels of MMP-8 (p < 0.001) as well as total protein, MMP-8/TIMP-1 ratio, bleeding on probing and plaque index (p = 0.05) compared with subjects without manifest caries. Multiple linear regression analysis with car-ies as the dependent variable revealed MMP-8 as the only significant explanatory variable (p < 0.001). TIMP-1 was not significant in any case. Using MMP-8 as the dependent vari-able revealed total protein concentration, caries lesions (p ≤ 0.001) and salivary secretion rate (p = 0.05) as explanatory variables. In conclusion, our data reveal that subjects with manifest caries lesions have elevated levels of salivary MMP-8 relative to subjects with no caries lesions.

  • 6.
    Hänsel Petersson, Gunnel
    et al.
    Malmö högskola, Odontologiska fakulteten (OD).
    Twetman, Svante
    Bratthall, Douglas
    Evaluation of a computer program for caries risk assessment in schoolchildren2002Inngår i: Caries Research, ISSN 0008-6568, E-ISSN 1421-976X, Vol. 36, nr 5, s. 327-340Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The 'Cariogram' is an interactive PC program for caries risk evaluation. It takes into account the interactions between caries-related factors and expresses a graphic assessment of the risk. The aim of this study was to assess the caries risk in schoolchildren using the Cariogram and to evaluate the program by comparing the caries risk assessments with the actual change in DMF. A 2-year prospective study on 446 schoolchildren, 10-11 years old, was conducted. At baseline, data on general health, diet, oral hygiene and use of fluoride were obtained. Saliva analyses included mutans streptococci and lactobacilli counts, buffer capacity and secretion rate. DMFT and DMFS were calculated from records and bitewing radiographs. Scores were entered and caries risk was assessed. Re-examination for caries was done after 2 years. The children were divided into 5 groups according to the assessed caries risk at baseline. Where the Cariogram predicted a 0-20% (high risk), 21-40%, 41-60%, 61-80% and 81-100% (low risk) chance of avoiding new lesions, 8, 35, 42, 73 and 83%, respectively, had no new lesions 2 years later. Logistic regression analyses were carried out. When the Cariogram was included, only two factors, the Cariogram (p < 0.001) and the DMFS at baseline, i.e. past caries experience (p = 0.001), turned out to be significantly associated with caries increment. The Cariogram was the most powerful explanatory variable. When the Cariogram was excluded, lactobacillus count, mutans streptococci, diet intake frequency and DMFS at baseline were significantly associated with caries increment. The Cariogram predicted caries increment more accurately than any included single-factor model. How this finding can be translated into daily practice in the best and most practical way is a matter for future research.

  • 7.
    Lager, Anders
    et al.
    Malmö högskola, Odontologiska fakulteten (OD).
    Thornqvist, Elisabeth
    Ericson, Dan
    Malmö högskola, Odontologiska fakulteten (OD).
    Cultivatable bacteria in dentine after caries excavation using rose-bur or carisolv2003Inngår i: Caries Research, ISSN 0008-6568, E-ISSN 1421-976X, Vol. 37, nr 3, s. 206-211Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    To measure the amount of viable bacteria after excavation using conventional rose-bur or the chemo-mechanical Carisolv method, a total of 22 lesions were analyzed (one vital tooth per patient) in this open, controlled and randomized study. Two samples per lesion were taken under aseptic conditions using a rose-bur, one superficially in the caries lesion and one after completed excavation. In in vitro tests more material was collected from the hard caries free dentine as compared to the carious dentine. The samples were incubated on blood agar (aerobically and anaerobically), Rogosa (SL) agar and mitis salivarius (MS) agar. For blood agar (aerobic) both methods resulted in a significant decrease in CFU, for blood agar (anaerobic) and MS agar only the Carisolv method resulted in a significant decrease in CFU and for SL agar neither method resulted in a significant decrease in CFU. Comparing CFU before and after excavation, a considerable reduction of CFU was seen ranging from 10(1) to 10(4). Comparing the excavation methods, there were no significant differences, except in the case of blood agar (aerobic), which showed that Carisolv excavation was more effective in reducing CFU. This study indicated that bacterial sampling collected more material from hard dentine as compared from soft. Remaining bacteria after excavation were low in both groups. The Carisolv method seemed to remove bacteria at least up to and possibly beyond the extent of conventional drilling.

  • 8.
    Mejàre, Ingegerd
    et al.
    Malmö högskola, Odontologiska fakulteten (OD).
    Stenlund, Hans
    Zelezny-Holmlund, C
    Caries Incidence and Lesion Progression from Adolescence to Young Adulthood. A Prospective 15-year Cohort Study in Sweden2004Inngår i: Caries Research, ISSN 0008-6568, E-ISSN 1421-976X, Vol. 38, nr 2, s. 130-141Artikkel i tidsskrift (Annet vitenskapelig)
    Abstract [en]

    The objectives were (1) to assess caries development, including the incidence and rate of lesion progression, in a Swedish cohort from adolescence to young adulthood and (2) to compare the caries incidence rates in adolescents with those of young adults. The original material consisted of 536 children aged 11-13 years at baseline. This cohort had been followed through annual bitewing radiographs to 21-22 years of age. In 1998-1999, 250 of these individuals were re-examined at the age of 26-27, and the new caries data were added to the original data. The results showed that fewer new enamel lesions developed on approximal surfaces during young adulthood than during adolescence; the caries incidence rates for enamel lesions decreased from 4.3 in the age group 12-15 years to 2.7 new caries lesions/100 surface-years in the age group 20-27 years. The same applied to the rate of lesion progression, where the corresponding values from the enamel-dentin border to the outer dentin were 32.5 for the youngest and 10.9 new lesions/100 surface-years for the oldest age group. The caries incidence of outer dentin lesions on approximal surfaces was low but increased from 0.2 in the age group 12-15 years to 0.9 new outer dentin lesions/100 surface-years in the age group 20-27 years. The incidence rates varied considerably between different tooth surfaces. Also for occlusal surfaces, fewer new dentin lesions developed during young adulthood than during adolescence; the incidence was 2.0 new dentin lesions/100 surface-years in the youngest age group and 0.7 during young adulthood. At the age of 13, the proportion of DFS of occlusal surfaces predominated over DFS of approximal surfaces but at the age of 26-27 the proportions of occlusal and approximal DFS were almost equal.

  • 9.
    Neilands, Jessica
    et al.
    Malmö högskola, Odontologiska fakulteten (OD).
    Petersson, Lars Gunnar
    Beighton, David
    Svensäter, Gunnel
    Malmö högskola, Odontologiska fakulteten (OD).
    Fluoride-supplemented milk inhibits acid tolerance in root caries biofilms2012Inngår i: Caries Research, ISSN 0008-6568, E-ISSN 1421-976X, Vol. 46, nr 2, s. 156-160Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    In this study we investigated the effect of fluoride on plaque acid tolerance. The test group consumed 200 ml of milk supplemented with 5 mg F/l as NaF once a day, the milk control group drank 200 ml of unsupplemented milk, and the no-milk control group did not consume milk in this manner. Plaque samples were taken at baseline and after 15 months. The proportion of acid-tolerant bacteria in plaque was estimated using LIVE/DEAD® BacLight™ staining after exposure to pH 3.5 for 2 h. The fluoride group showed a statistically significant decrease in plaque acid tolerance compared to baseline. This study shows that daily intake of fluoride in milk reduces plaque acid tolerance.

    Fulltekst (pdf)
    FULLTEXT01
  • 10.
    Neilands, Jessica
    et al.
    Malmö högskola, Odontologiska fakulteten (OD).
    Sutherland, Donald
    Resin, Anton
    Wejse, Peter Langborn
    Chávez de Paz, Luis Eduardo
    Chitosan Nanoparticles Affect the Acid Tolerance Response in Adhered Cells of Streptococcus mutans2011Inngår i: Caries Research, ISSN 0008-6568, E-ISSN 1421-976X, Vol. 45, nr 6, s. 501-505Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    In this study we evaluated the effect of chitosan nanoparticles on the acid tolerance response (ATR) of adhered Streptococcus mutans. An ATR was induced by exposing S. mutans to pH 5.5 for 2 h and confirmed by exposing the acid-adapted cells to pH 3.5 for 30 min, with the majority of cells appearing viable according to the LIVE/DEAD® technique. However, when chitosan nanoparticles were present during the exposure to pH 5.5, no ATR occurred as most cells appeared dead after the pH 3.5 shock. We conclude that the chitosan nanoparticles tested had the ability to hinder ATR induction in adhered S. mutans.

    Fulltekst (pdf)
    FULLTEXT01
  • 11.
    Ridell, Karin
    et al.
    Malmö högskola, Odontologiska fakulteten (OD).
    Olsson, Helena
    Malmö högskola, Odontologiska fakulteten (OD).
    Mejàre, Ingegerd
    Malmö högskola, Odontologiska fakulteten (OD).
    Unrestored dentin caries and deep dentin restorations in Swedish adolescents2008Inngår i: Caries Research, ISSN 0008-6568, E-ISSN 1421-976X, Vol. 42, nr 3, s. 164-170Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The objectives of this longitudinal study were to assess: (a) the prevalence of unrestored dentin caries among 15-year-olds, (b) the proportion of these lesions that had progressed to deep dentin lesions (inner half of dentin) since the immediately preceding examination at the age of 14 and (c) the frequency of deep restorations (extending into the inner half of the dentin). The sample consisted of all 15-year-olds (n = 2,487) born in 1990 and included in the Public Dental Service in Malmo, Sweden. Bitewing radiographs taken during 2005-2007 and the immediately preceding radiographs were analysed and scored by two examiners. The main radiographic scores were: sound; radiolucency in the outer or inner half of dentin; restored surface. The results showed that 22% of the individuals had 1 or more dentin lesions left unrestored from the time of the examination at the age of 14 until the next recall examination at the age of 15. During the observation period (median time 1.2 years), 9% of the unrestored outer dentin lesions progressed to deep dentin lesions. The majority of these (93%) were in molars. One or more deep restorations were found in 22% of the 15-year-olds; the majority involved occlusal surfaces of first molars. In conclusion, unrestored dentin lesions were common in 15-year-olds. Progression to deep dentin lesions occurred in 9% of these lesions and was most common in first molars. Occlusal surfaces of first molars had the highest frequency of deep restorations. (c) 2008 S. Karger AG, Basel

  • 12.
    Sotres, Javier
    et al.
    Malmö högskola, Fakulteten för hälsa och samhälle (HS), Institutionen för biomedicinsk vetenskap (BMV).
    Barrantes, Alejandro
    Malmö högskola, Fakulteten för hälsa och samhälle (HS), Institutionen för biomedicinsk vetenskap (BMV).
    Lindh, Liselott
    Malmö högskola, Odontologiska fakulteten (OD).
    Arnebrant, Thomas
    Malmö högskola, Fakulteten för hälsa och samhälle (HS), Institutionen för biomedicinsk vetenskap (BMV).
    Strategies for a Direct Characterization of Phosphoproteins on Hydroxyapatite Surfaces2014Inngår i: Caries Research, ISSN 0008-6568, E-ISSN 1421-976X, Vol. 48, nr 2, s. 98-110Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    We show in this work how systems formed by phosphoproteins on calcium phosphate surfaces can be directly characterized, in real time, in liquid medium, without the need for elution or labeling. Specifically, we show how this is possible by applying three different techniques: ellipsometry, quartz crystal microbalance with dissipation, and atomic force microscopy-based friction force spectroscopy. We apply these techniques to study two different model systems, i.e. those formed upon the adsorption of two model phosphoproteins (κ- and β-casein) on hydroxyapatite (HA) surfaces. Information on the kinetics of adsorption, surface excess, viscoelasticity, water content, thickness of the layers, and protein-surface interaction is provided. Results indicate that both phosphoproteins form homogeneous elastic highly hydrated monolayers on the HA surfaces, the strength of β-casein layers being higher by approximately a factor of 4. Based on the experimental results, models for the conformation of κ- and β-casein molecules adsorbed on HA surfaces are proposed.

  • 13.
    Svensäter, Gunnel
    et al.
    Malmö högskola, Odontologiska fakulteten (OD).
    Borgström, M
    Bowden, George H W
    Edwardsson, S
    The acid-tolerant microbiota associated with plaque from initial caries and healthy tooth surfaces2003Inngår i: Caries Research, ISSN 0008-6568, E-ISSN 1421-976X, Vol. 37, nr 6, s. 395-403Artikkel i tidsskrift (Annet vitenskapelig)
    Abstract [en]

    The intent of this study was to compare the inherent acid tolerance of bacteria in samples of dental plaque from tooth sites in subjects with and without initial caries. Plaque was collected from approximal surfaces showing early enamel caries and from healthy tooth surfaces in the same subjects, as well as from enamel surfaces of caries-free individuals. In addition to plating on blood agar, the plaque samples were plated directly on non-selective solid agar medium buffered to pH 7.0, 6.0, 5.5, 5.0, 4.5 and 4.0 to avoid any loss of adaptation to acid during primary isolation of plaque bacteria. The results showed that approximately 50% of the total cultivable plaque microbiota from caries, as well as healthy tooth sites, was able to grow at pH 5.5 and 1% at pH 5.0, pH values regarded as critical for the demineralization of tooth enamel. At pH 5.0, members of the genus Streptococcus were the dominant group, but mutans streptococci accounted for less than half of the streptococcal viable count. The other acid-tolerant streptococcal isolates included Streptococcus anginosus, Streptococcus constellatus, Streptococcus gordinii, Streptococcus intermedius, Streptococcus mitis, Streptococcus oralis, Streptococcus salivarius and SStreptococcus sanguis. Analysis of the results indicated that the mutans streptococci in dental plaque were highly variable with respect to acid tolerance, and that both caries and healthy sites harboured significant numbers of mutans streptococci that were not acid-tolerant.

  • 14. Valentijn-Benz, Marianne
    et al.
    van 't Hof, Wim
    Bikker, Floris J
    Nazmi, Kamran
    Brand, Henk S
    Sotres, Javier
    Malmö högskola, Fakulteten för hälsa och samhälle (HS), Institutionen för biomedicinsk vetenskap (BMV).
    Lindh, Liselott
    Malmö högskola, Odontologiska fakulteten (OD).
    Arnebrant, Thomas
    Malmö högskola, Fakulteten för hälsa och samhälle (HS), Institutionen för biomedicinsk vetenskap (BMV).
    Veerman, Enno C I
    Sphingoid Bases Inhibit Acid-Induced Demineralization of Hydroxyapatite2015Inngår i: Caries Research, ISSN 0008-6568, E-ISSN 1421-976X, Vol. 49, nr 1, s. 9-17Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Calcium hydroxyapatite (HAp), the main constituent of dental enamel, is inherently susceptible to the etching and dissolving action of acids, resulting in tooth decay such as dental caries and dental erosion. Since the prevalence of erosive wear is gradually increasing, there is urgent need for agents that protect the enamel against erosive attacks. In the present study we studied in vitro the anti-erosive effects of a number of sphingolipids and sphingoid bases, which form the backbone of sphingolipids. Pretreatment of HAp discs with sphingosine, phytosphingosine (PHS), PHS phosphate and sphinganine significantly protected these against acid-induced demineralization by 80 ± 17%, 78 ± 17%, 78 ± 7% and 81 ± 8%, respectively (p < 0.001). On the other hand, sphingomyelin, acetyl PHS, octanoyl PHS and stearoyl PHS had no anti-erosive effects. Atomic force measurement revealed that HAp discs treated with PHS were almost completely and homogeneously covered by patches of PHS. This suggests that PHS and other sphingoid bases form layers on the surface of HAp, which act as diffusion barriers against H+ ions. In principle, these anti-erosive properties make PHS and related sphingosines promising and attractive candidates as ingredients in oral care products.

1 - 14 of 14
RefereraExporteraLink til resultatlisten
Permanent link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf