This report is the result of a pilot study with the ambition of connecting social entrepreneurship with the values of the Biosphere reserve, for development of innovative enterprise. The preliminary study is comprised of three parts: a new definition of the concept of social entrepreneurship in relation to the conditions and circumstances of the Biosphere reserve (Biosphere Entrepreneurship); an analysis of the present situation and future needs; and a description of an innovation system and a model for social entrepreneurship in the Biosphere reserve (Biosphere Innovation System).