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  • 1.
    Ali, Abdullah
    Malmö universitet, Fakulteten för hälsa och samhälle (HS), Institutionen för biomedicinsk vetenskap (BMV).
    Topical formulations, design and drug delivery: "A dive into water"2021Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
    Abstract [en]

    Water is a vital component regulating the properties of topical formulations and their interaction with biological barriers, such as skin and mucosa. Changing the watercontent within the frame of the pharmaceutical triangle will have a huge impact on which type of formulation, such as a cream, ointment, gel, or lotion, is formed, as well as the physical properties of the formulation. The composition of a formulation, and the subsequent reformulation after application, will govern the features of the residual film. This will in turn affect the barrier properties of the underlying tissue and consequently the penetration of various substances across skin or mucosa.The primary aim of this thesis has been to provide further understanding on differences between traditional surfactant-based formulations and particle-stabilized, Pickering, formulations and how specific excipients, like alcohols, emollients, and thickeners can affect their physical and/or sensorial properties. The secondary aim has been to gain more knowledge on the role of water in topical formulations and how it affects the properties of the underlaying tissue on application.

    By combining a portfolio of physicochemical techniques combined with sensory science, we have been able to identify differences between Pickering and surfactantstabilized formulations. Starch-based Pickering emulsions were perceived as less greasy and sticky than traditional creams, even at high oil content. Moreover, we were able develop a novel type of alcohol-based Pickering emulsion with combined moisturizing and antiseptic properties. We have also been able to link sensory attributes, evaluated by human volunteers, with physicochemical characterizations. Furthermore, the in vitro ForceBoard™ method was developed further and we evaluated its potential to be used as an ex vivo method using excised skin. In addition, we have shown that that the water gradient over a biological barrier has a general relevance with respect to drug absorption and should be considered not only in dermaldrug delivery but also for buccal and nasal drug delivery.

    Delarbeten
    1. Relationship between sensorial and physical characteristics of topical creams: a comparative study of effects of excipients
    Öppna denna publikation i ny flik eller fönster >>Relationship between sensorial and physical characteristics of topical creams: a comparative study of effects of excipients
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    2022 (Engelska)Ingår i: International Journal of Pharmaceutics, ISSN 0378-5173, E-ISSN 1873-3476, Vol. 613, s. 1-12, artikel-id 121370Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    Rising consumer demands for safer, more natural, and sustainable topical products have led to increased interest in finding alternative excipients, while retaining functionality and cosmetic appeal. Particle-stabilized Pickering creams have emerged as possible alternatives to replace traditional surfactant-stabilized creams and are thus one of the focuses in this study. The aim of this paper was to study relationships between sensorial characteristics and physical properties to understand how different excipients affect these aspects, comparing one starch particle–stabilized and three surfactant-stabilized formulations. A human panel was used to evaluate sensorial perception, while physical properties were deduced by rheology and tactile friction, together with in vivo and ex vivo skin hydration measurements.

    The results show that sensorial attributes related to the application phase can be predicted with rheology, while afterfeel attributes can be predicted with tactile friction studies. Differences in rheological and sensory properties among surfactant-based creams could mainly be attributed to the type of emollients used, presence of thickeners and surfactant composition. Differences between surfactant-based creams and a Pickering cream were more evident in relation to the afterfeel perception. Presence of starch particles in the residual film on skin results in high tactile friction and low perception of residual coating, stickiness, greasiness, and slipperiness in sensorial afterfeel.

    Ort, förlag, år, upplaga, sidor
    Elsevier, 2022
    Nationell ämneskategori
    Medicinska och farmaceutiska grundvetenskaper
    Identifikatorer
    urn:nbn:se:mau:diva-44945 (URN)10.1016/j.ijpharm.2021.121370 (DOI)000736963200004 ()34952146 (PubMedID)2-s2.0-85122426677 (Scopus ID)
    Tillgänglig från: 2021-08-18 Skapad: 2021-08-18 Senast uppdaterad: 2024-06-17Bibliografiskt granskad
    2. Tactile friction of topical creams and emulsions: Friction measurements on excised skin and VitroSkin® using ForceBoard™.
    Öppna denna publikation i ny flik eller fönster >>Tactile friction of topical creams and emulsions: Friction measurements on excised skin and VitroSkin® using ForceBoard™.
    Visa övriga...
    2022 (Engelska)Ingår i: International Journal of Pharmaceutics, ISSN 0378-5173, E-ISSN 1873-3476, Vol. 615, artikel-id 121502Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    Tactile perception can be investigated through ex vivo friction measurements using a so-called ForceBoard™, providing objective assessments and savings in time and money, compared to a subjective human panel. In this work we aim to compare excised skin versus VitroSkin® as model substrates for tactile friction measurements. A further aim is to detect possible differences between traditional surfactant-based creams, and a particle-stabilized (Pickering) cream and investigate how the different substrates affect the results obtained. It was found that the difference in tactile friction between excised skin and VitroSkin® was small on untreated substrates. When topical creams were applied, the same trends were observed for both substrates, although the frictional variation over time relates to the difference in surface structure between the two substrates. The results also confirmed that there is a difference between starch-based Pickering formulations and surfactant-based creams after application, indicating that the latter is greasier than Pickering cream. It was also shown that the tactile friction of Pickering emulsions was consistently high even with high amounts of oil, indicating a non-greasy, and non-sticky formulation. The characteristics of starch-stabilized Pickering formulations make them promising candidates in the development of surfactant-free topical formulations with unique tactile properties.

    Ort, förlag, år, upplaga, sidor
    Elsevier, 2022
    Nyckelord
    Excised skin, Force-Board™, Pickering emulsions, Surfactant-free formulations, Tactile friction, Topical creams, VitroSkin®
    Nationell ämneskategori
    Livsmedelsteknik
    Identifikatorer
    urn:nbn:se:mau:diva-50117 (URN)10.1016/j.ijpharm.2022.121502 (DOI)000781015400004 ()35091002 (PubMedID)2-s2.0-85123703718 (Scopus ID)
    Tillgänglig från: 2022-02-14 Skapad: 2022-02-14 Senast uppdaterad: 2024-02-05Bibliografiskt granskad
    3. Alcohol-based Pickering emulsions as moisturizing topical handsanitizers
    Öppna denna publikation i ny flik eller fönster >>Alcohol-based Pickering emulsions as moisturizing topical handsanitizers
    Visa övriga...
    2021 (Engelska)Manuskript (preprint) (Övrigt vetenskapligt)
    Nationell ämneskategori
    Medicin och hälsovetenskap
    Identifikatorer
    urn:nbn:se:mau:diva-44963 (URN)
    Tillgänglig från: 2021-08-18 Skapad: 2021-08-18 Senast uppdaterad: 2023-04-15Bibliografiskt granskad
    4. Will a water gradient in oral mucosa affect transbuccal drug absorption?
    Öppna denna publikation i ny flik eller fönster >>Will a water gradient in oral mucosa affect transbuccal drug absorption?
    2018 (Engelska)Ingår i: Journal of Drug Delivery Science and Technology, ISSN 1773-2247, Vol. 48, s. 338-345Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    Formulations for buccal drug delivery often comprise polymers to facilitate mucoadhesion based on water sorption. The main objective of the current study was therefore to evaluate the effect of dehydration on drug uptake through oral mucosa. We have used diffusion cells with excised porcine mucosa to study uptake of three alternative drugs (i.e., Metronidazole, Benzydamine and Xylometazoline) together with polyethylene glycol (PEG) as the model polymer for adjusting water activity in the test solutions. Taking drug activity into account, we can conclude that addition of PEG results in a drug flux through mucosa that is about two times lower for Metronidazole and more than 40 times lower for Xylometazoline compared to that from a pure PBS-solution. However, for Benzydamine the uptake through mucosa was more or less the same, which could possibly be due to the high PEG-concentration (65 wt%) affecting the dissociation constant and thus the permeability. These results indicate that an increased water gradient may have the same limiting effect on permeability through oral mucosa as previously seen for skin. Thus, water gradient effects should be a factor to consider when developing buccal adhesive formulations.

    Ort, förlag, år, upplaga, sidor
    Elsevier, 2018
    Nyckelord
    Buccal drug delivery, Oral mucosa, Permeability, Hydration, Drug transport, Formulation
    Nationell ämneskategori
    Farmaceutiska vetenskaper
    Identifikatorer
    urn:nbn:se:mau:diva-15172 (URN)10.1016/j.jddst.2018.10.004 (DOI)000451008000038 ()2-s2.0-85055034037 (Scopus ID)27250 (Lokalt ID)27250 (Arkivnummer)27250 (OAI)
    Tillgänglig från: 2020-03-30 Skapad: 2020-03-30 Senast uppdaterad: 2024-02-05Bibliografiskt granskad
    5. Dehydration affects drug transport over nasal mucosa
    Öppna denna publikation i ny flik eller fönster >>Dehydration affects drug transport over nasal mucosa
    Visa övriga...
    2019 (Engelska)Ingår i: Drug Delivery, ISSN 1071-7544, E-ISSN 1521-0464, Vol. 26, nr 1, s. 831-840Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    Formulations for nasal drug delivery often rely on water sorption to adhere to the mucosa, which also causes a higher water gradient over the tissue and subsequent dehydration. The primary aim of this study was therefore to evaluate mucosal response to dehydration and resolve the hypothesis that mucoadhesion achieved through water sorption could also be a constraint for drug absorption via the nasal route. The effect of altering water activity of the vehicle on Xylometazoline HCl and Cr-EDTA uptake was studied separately using flow through diffusion cells and excised porcine mucosa. We have shown that a modest increase in the water gradient over mucosa induces a substantial decrease in drug uptake for both Xylometazoline HCl and Cr-EDTA. A similar result was obtained when comparing two different vehicles on the market; Nasoferm (Nordic Drugs, Sweden) and BLOX4 (Bioglan, Sweden). Mucoadhesion based on water sorption can slow down drug uptake in the nasal cavity. However, a clinical study is required to determine whether prolonged duration of the vehicle or preventing dehydration of the mucosa is the most important factor for improving bioavailability.

    Ort, förlag, år, upplaga, sidor
    Taylor & Francis, 2019
    Nyckelord
    Mucoadhesion, dehydration, drug transport, nasal drug delivery, water activity
    Nationell ämneskategori
    Farmaceutiska vetenskaper
    Identifikatorer
    urn:nbn:se:mau:diva-15215 (URN)10.1080/10717544.2019.1650848 (DOI)000480247200001 ()31401887 (PubMedID)2-s2.0-85071047269 (Scopus ID)29688 (Lokalt ID)29688 (Arkivnummer)29688 (OAI)
    Tillgänglig från: 2020-03-30 Skapad: 2020-03-30 Senast uppdaterad: 2024-02-05Bibliografiskt granskad
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  • 2.
    Ali, Abdullah
    et al.
    Malmö universitet, Fakulteten för hälsa och samhälle (HS), Institutionen för biomedicinsk vetenskap (BMV). Malmö universitet, Biofilms Research Center for Biointerfaces. Speximo AB, Medicon Village, Lund.
    Ringstad, Lovisa
    RISE Research Institutes of Sweden, Bioeconomy and Health, Stockholm.
    Skedung, Lisa
    RISE Research Institutes of Sweden, Bioeconomy and Health, Stockholm.
    Falkman, Peter
    Malmö universitet, Fakulteten för hälsa och samhälle (HS), Institutionen för biomedicinsk vetenskap (BMV). Malmö universitet, Biofilms Research Center for Biointerfaces.
    Wahlgren, Marie
    Food Technology, Engineering and Nutrition, Lund University.
    Engblom, Johan
    Malmö universitet, Fakulteten för hälsa och samhälle (HS), Institutionen för biomedicinsk vetenskap (BMV). Malmö universitet, Biofilms Research Center for Biointerfaces.
    Tactile friction of topical creams and emulsions: Friction measurements on excised skin and VitroSkin® using ForceBoard™.2022Ingår i: International Journal of Pharmaceutics, ISSN 0378-5173, E-ISSN 1873-3476, Vol. 615, artikel-id 121502Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Tactile perception can be investigated through ex vivo friction measurements using a so-called ForceBoard™, providing objective assessments and savings in time and money, compared to a subjective human panel. In this work we aim to compare excised skin versus VitroSkin® as model substrates for tactile friction measurements. A further aim is to detect possible differences between traditional surfactant-based creams, and a particle-stabilized (Pickering) cream and investigate how the different substrates affect the results obtained. It was found that the difference in tactile friction between excised skin and VitroSkin® was small on untreated substrates. When topical creams were applied, the same trends were observed for both substrates, although the frictional variation over time relates to the difference in surface structure between the two substrates. The results also confirmed that there is a difference between starch-based Pickering formulations and surfactant-based creams after application, indicating that the latter is greasier than Pickering cream. It was also shown that the tactile friction of Pickering emulsions was consistently high even with high amounts of oil, indicating a non-greasy, and non-sticky formulation. The characteristics of starch-stabilized Pickering formulations make them promising candidates in the development of surfactant-free topical formulations with unique tactile properties.

    Ladda ner fulltext (pdf)
    fulltext
  • 3.
    Ali, Abdullah
    et al.
    Malmö universitet, Fakulteten för hälsa och samhälle (HS), Institutionen för biomedicinsk vetenskap (BMV). Speximo AB, Medicon Village, SE-223 81 Lund, Sweden.
    Skedung, L
    RISE Research Institutes of Sweden, Bioeconomy and Health, Perception and Design, Stockholm, Sweden.
    Burleigh, S
    Food Technology, Engineering and Nutrition, Lund University, Lund, Sweden.
    Lavant, Eva
    Malmö universitet, Fakulteten för hälsa och samhälle (HS), Institutionen för biomedicinsk vetenskap (BMV). Malmö universitet, Biofilms Research Center for Biointerfaces.
    Ringstad, L
    RISE Research Institutes of Sweden, Bioeconomy and Health, Perception and Design, Stockholm, Sweden.
    Andersson, CD
    Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
    Wahlgren, M
    Food Technology, Engineering and Nutrition, Lund University, Lund, Sweden.
    Engblom, Johan
    Malmö universitet, Fakulteten för hälsa och samhälle (HS), Institutionen för biomedicinsk vetenskap (BMV). Malmö universitet, Biofilms Research Center for Biointerfaces.
    Relationship between sensorial and physical characteristics of topical creams: a comparative study of effects of excipients2022Ingår i: International Journal of Pharmaceutics, ISSN 0378-5173, E-ISSN 1873-3476, Vol. 613, s. 1-12, artikel-id 121370Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Rising consumer demands for safer, more natural, and sustainable topical products have led to increased interest in finding alternative excipients, while retaining functionality and cosmetic appeal. Particle-stabilized Pickering creams have emerged as possible alternatives to replace traditional surfactant-stabilized creams and are thus one of the focuses in this study. The aim of this paper was to study relationships between sensorial characteristics and physical properties to understand how different excipients affect these aspects, comparing one starch particle–stabilized and three surfactant-stabilized formulations. A human panel was used to evaluate sensorial perception, while physical properties were deduced by rheology and tactile friction, together with in vivo and ex vivo skin hydration measurements.

    The results show that sensorial attributes related to the application phase can be predicted with rheology, while afterfeel attributes can be predicted with tactile friction studies. Differences in rheological and sensory properties among surfactant-based creams could mainly be attributed to the type of emollients used, presence of thickeners and surfactant composition. Differences between surfactant-based creams and a Pickering cream were more evident in relation to the afterfeel perception. Presence of starch particles in the residual film on skin results in high tactile friction and low perception of residual coating, stickiness, greasiness, and slipperiness in sensorial afterfeel.

    Ladda ner fulltext (pdf)
    fulltext
  • 4.
    Ali, Abdullah
    et al.
    Malmö universitet, Fakulteten för hälsa och samhälle (HS), Institutionen för biomedicinsk vetenskap (BMV).
    Thuresson, S
    Anderson, C D
    Falkman, P
    Kocherbitov, V
    Ringstad, L
    Sjöö, M
    Skenderska, A
    Wahlgren, M
    Engblom, J
    Alcohol-based Pickering emulsions as moisturizing topical handsanitizers2021Manuskript (preprint) (Övrigt vetenskapligt)
  • 5.
    Ali, Abdullah
    et al.
    Malmö universitet, Fakulteten för hälsa och samhälle (HS), Institutionen för biomedicinsk vetenskap (BMV). Malmö universitet, Biofilms Research Center for Biointerfaces.
    Wahlgren, Marie
    Food Technology, Engineering and Nutrition, Lund University, P.O. Box 124, SE-221 00, Lund, Sweden.
    Pedersen, Lina
    Malmö universitet, Fakulteten för hälsa och samhälle (HS), Institutionen för biomedicinsk vetenskap (BMV). Malmö universitet, Biofilms Research Center for Biointerfaces.
    Engblom, Johan
    Malmö universitet, Fakulteten för hälsa och samhälle (HS), Institutionen för biomedicinsk vetenskap (BMV). Malmö universitet, Biofilms Research Center for Biointerfaces.
    Will a water gradient in oral mucosa affect transbuccal drug absorption?2018Ingår i: Journal of Drug Delivery Science and Technology, ISSN 1773-2247, Vol. 48, s. 338-345Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Formulations for buccal drug delivery often comprise polymers to facilitate mucoadhesion based on water sorption. The main objective of the current study was therefore to evaluate the effect of dehydration on drug uptake through oral mucosa. We have used diffusion cells with excised porcine mucosa to study uptake of three alternative drugs (i.e., Metronidazole, Benzydamine and Xylometazoline) together with polyethylene glycol (PEG) as the model polymer for adjusting water activity in the test solutions. Taking drug activity into account, we can conclude that addition of PEG results in a drug flux through mucosa that is about two times lower for Metronidazole and more than 40 times lower for Xylometazoline compared to that from a pure PBS-solution. However, for Benzydamine the uptake through mucosa was more or less the same, which could possibly be due to the high PEG-concentration (65 wt%) affecting the dissociation constant and thus the permeability. These results indicate that an increased water gradient may have the same limiting effect on permeability through oral mucosa as previously seen for skin. Thus, water gradient effects should be a factor to consider when developing buccal adhesive formulations.

  • 6.
    Ali, Abdullah
    et al.
    Malmö universitet, Fakulteten för hälsa och samhälle (HS), Institutionen för biomedicinsk vetenskap (BMV). Malmö universitet, Biofilms Research Center for Biointerfaces.
    Wahlgren, Marie
    Food Technology, Engineering and Nutrition, Lund University, Lund, Sweden.
    Rembratt-Svensson, Birgitta
    Bioglan AB, Malmö, Sweden.
    Daftani, Ameena
    Malmö universitet, Fakulteten för hälsa och samhälle (HS), Institutionen för biomedicinsk vetenskap (BMV). Malmö universitet, Biofilms Research Center for Biointerfaces.
    Falkman, Peter
    Malmö universitet, Fakulteten för hälsa och samhälle (HS), Institutionen för biomedicinsk vetenskap (BMV). Malmö universitet, Biofilms Research Center for Biointerfaces.
    Wollmer, Per
    Department of Translational Medicine, Faculty of Medicine, Lund University, Malmö, Sweden.
    Engblom, Johan
    Malmö universitet, Fakulteten för hälsa och samhälle (HS), Institutionen för biomedicinsk vetenskap (BMV). Malmö universitet, Biofilms Research Center for Biointerfaces.
    Dehydration affects drug transport over nasal mucosa2019Ingår i: Drug Delivery, ISSN 1071-7544, E-ISSN 1521-0464, Vol. 26, nr 1, s. 831-840Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Formulations for nasal drug delivery often rely on water sorption to adhere to the mucosa, which also causes a higher water gradient over the tissue and subsequent dehydration. The primary aim of this study was therefore to evaluate mucosal response to dehydration and resolve the hypothesis that mucoadhesion achieved through water sorption could also be a constraint for drug absorption via the nasal route. The effect of altering water activity of the vehicle on Xylometazoline HCl and Cr-EDTA uptake was studied separately using flow through diffusion cells and excised porcine mucosa. We have shown that a modest increase in the water gradient over mucosa induces a substantial decrease in drug uptake for both Xylometazoline HCl and Cr-EDTA. A similar result was obtained when comparing two different vehicles on the market; Nasoferm (Nordic Drugs, Sweden) and BLOX4 (Bioglan, Sweden). Mucoadhesion based on water sorption can slow down drug uptake in the nasal cavity. However, a clinical study is required to determine whether prolonged duration of the vehicle or preventing dehydration of the mucosa is the most important factor for improving bioavailability.

    Ladda ner fulltext (pdf)
    FULLTEXT01
  • 7.
    Sjöö, M.
    et al.
    Speximo AB, Medicon Village, SE-223 81, Lund, Sweden; Department of Food Technology Engineering and Nutrition, Lund University, PO Box 124, SE-221 00 Lund, Sweden.
    Bedi, J
    Speximo AB, Medicon Village, SE-223 81, Lund.
    Ali, Abdullah
    Malmö högskola, Fakulteten för hälsa och samhälle (HS), Institutionen för biomedicinsk vetenskap (BMV). Malmö högskola, Biofilms Research Center for Biointerfaces. Speximo AB, Medicon Village, SE-223 81, Lund.
    Novel encapsulation technology based on Pickering emulsion systems2016Ingår i: Advanced Materials - TechConnect Briefs 2016, TechConnect , 2016, Vol. 1, s. 312-315Konferensbidrag (Refereegranskat)
    Abstract [en]

    A novel technology based on using particles of biological origin was recently developed for stabilising emulsions. This technology, that utilises Pickering emulsions, was further employed to encapsulate different types of active substances. Advance development and refinement of the technology has been performed in order to suit different encapsulation purposes in areas within personal care, food and pharmaceuticals. Some areas where this technology has been tested include taste masking in food systems, encapsulation and protection of a cosmetic active, production of oil filled powder encapsulates, and on-skin performance.  

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