As global climate change intensifies, the question of what makes a place habitable or uninhabitable is critical, particularly in the context of a potential future climate outside the realm of lived experience, and the possible concurrent redistribution of populations partly associated with such climatic shifts. The concept of habitability holds the potential for advancing the understanding of the societal consequences of climate change, as well as for integrating systemic understandings and rights-based approaches. However, most ways of analyzing habitability have shortcomings in terms of in-depth integration of socio-cultural aspects and human agency in shaping habitability, in failing to address spatial inequalities and power dynamics, and in an underemphasis of the connectedness of places. Here we elaborate habitability as an emergent property of the relations between people and a given place that results from people's interactions with the material and immaterial properties of a place. From this, we identify four axes that are necessary to go beyond environmental changes, and to encompass socio-cultural, economic, and political dynamics: First the processes that influence habitability require a systemic approach, viewing habitability as an outcome of ecological, economic, and political processes. Second, the role of socio-cultural dimensions of habitability requires special consideration, given their own operational logics and functioning of social systems. Third, habitability is not the same for everyone, thus a comprehensive understanding of habitability requires an intersectionally differentiated view on social inequalities. Forth, the influence of external factors necessitates a spatially relational perspective on places in the context of their connections to distant places across scales. We identify key principles that should guide an equitable and responsible research agenda on habitability. Analysis should be based on disciplinary and methodological pluralism and the inclusion of local perspectives. Habitability action should integrate local perspectives with measures that go beyond purely subjective assessments. And habitability should consider the role of powerful actors, while staying engaged with ethical questions of who defines and enacts the future of any given place.