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Detektion och kvantifiering av ökade halter bakterier i plasma, inducerat av intensiv fysisk aktivitet
Malmö University, Faculty of Health and Society (HS).
2021 (Swedish)Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesisAlternative title
Detection and quantification of increased bacteria in plasma, induced by intense physical activity (English)
Abstract [sv]

Bland atleter är gastrointestinala symptom som diarré, illamående och kräkning vanliga. Faktorer och mekanismerna bakom de träningsinducerade symptomen utreds ännu. Under intensiv träning utsätts de gastrointestinala symptomen för hypoperfusion vilket kan leda till hypoxi. Den oxidativa stressen kan i sin tur påverka tarmbarriärens funktion negativt och orsaka skador. Bland tidigare studier har tarmpermeabilitet och ökade halter av markörer för cellskador i tarmen observerats. I denna studie undersöktes nivån av bakterier i blodet då det möjligtvis kan ha frisatts från tarmen genom ökad permeabilitet. Ökade halter E.coli bakterier i plasma bland majoriteten deltagare upptäcktes, orsakad av hypoperfusion resulterat i ökad tarmpermeabilitet.

Abstract [en]

Among athletes, gastrointestinal symptoms such as diarrhea, nausea and vomiting are common. Factors and mechanisms behind the exercise induced symptoms are still being investigated. During intense training, the gastrointestinal symptoms are exposed to hypoperfusion, which can lead to hypoxia. The oxidative stress can in turn adversely affect the function of the intestinal barrier and cause damage. Among previous studies, intestinal permeability and increased levels of markers for intestinal cell damage have been observed. In this study, the level of bacteria in the blood was examined as it may have been released from the intestine through increased permeability. Increased levels of E. coli bacteria in plasma among the majority of participants were detected, caused by hypoperfusion resulting in increased intestinal permeability.

Place, publisher, year, edition, pages
2021. , p. 21
Keywords [en]
Diarrhea, E. coli, Intestinal barrier, Intestinal permeability, Nausea, qPCR, Vomiting
Keywords [sv]
Diarré, E.coli, Illamående, Kräkning, Tarmbarriär, Tarmpermeabilitet, qPCR
National Category
Public Health, Global Health and Social Medicine
Identifiers
URN: urn:nbn:se:mau:diva-44508OAI: oai:DiVA.org:mau-44508DiVA, id: diva2:1577686
Educational program
HS Biomedicinsk laboratorievetenskap
Supervisors
Examiners
Available from: 2021-11-10 Created: 2021-07-03 Last updated: 2025-02-20Bibliographically approved

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