In my research and review of several peer reviewed articles in these book, show that higher education faces major challenges both pedagogically and technically (Amhag, 2011; 2012; 2013a; 2013b; 2016a; 2016b; 2017; 2020; Amhag, Hellstrom & Stigmar, 2019; Amhag & Jakobsson, 2009). In the articles provides several opportunities to design and teach for self-directed and motivated higher education with smart pedagogy in a resource-enriched virtual learning environment, VLE through technology-embedded blended prerequisite and activities across various dimensions, including the notion that students can learn self-directed at anywhere and anytime, and easily switch learning contexts to another or a variety of scenarios. These blended learning activities combines both in- and out-off the university and during practical training in the profession by using face-to-face, F2F classroom lessons, teacher-recorded flipped lesson videos and mobile online webinars F2F with chat communications that contribute to increase internationalization, globalization and digitization of higher education.