This retrospective study evaluated hard and soft tissue response and reported mechanical and technical complications around computer-aided design/computer-assisted manufactured (CAD/CAM) abutments. A total of 123 patients restored with titanium, gold-hue titanium, and zirconia CAD/CAM abutments were included (N = 291). Each patient was followed up for at least 2 years. Clinical and radiographic parameters were assessed annually and complications were recorded. No implant or reconstruction failures were reported. One fracture of a zirconia abutment occurred. The prosthetic survival rate after 4 years of function for restorations and abutments was 100% and 99.66%, respectively. No significant differences in biologic and radiographic indices were found. The bleeding on probing index was positive at 42% of implant sites, and it had no significant correlation with the overall change in marginal bone level (0.02 mm) of bone gain. The short-term survival of CAD/CAM abutments was reliable, no matter of the material used for manufacturing.