Psychological interviews, whether clinical or research oriented, are constituted by an interpersonal, social context in which epistemic and ethical purposes are at stake. Interviews are commonly categorized as (1) structured, (2) unstructured, or (3) semistructured. These different formats have their pros and cons, both in relation to epistemic and/or ethical purposes and/or methodological issues. The recent developments of qualitative research methods in psychology have initiated and raised epistemological concerns over what theory of science would be most appropriate for a psychological science in which interviews are used as a data collection procedure. Such concerns can be directly linked to the three different interview formats and, in a theoretical sense, to the different theoretical perspectives in psychology.