Expression of PTEN and SHP1, investigated from tissue micro arrays in pediatric acute lymphoblastic leukaemiaShow others and affiliations
2009 (English)In: Pediatric Hematology & Oncology, ISSN 0888-0018, E-ISSN 1521-0669, Vol. 26, no 1, p. 48-56Article in journal (Refereed) Published
Abstract [en]
PTEN and SHP1 are tumor suppressor genes involved in the regulation of cell cycle control and apoptosis. We have investigated the protein expression of PTEN and SHP 1, by immunohistochemistry in micro tissue arrays from bone marrow samples in children, diagnosed with acute lymphoblastic leukaemia and non-malignant controls. PTEN was over expressed in ALL samples, while SHP1 showed a low expression. PTEN showed a significant difference in expression compared to non-malignant controls. The role of PTEN and SHP1 are not well investigated in pediatric leukemias and could in future play a role as prognostic factors.
Place, publisher, year, edition, pages
Informa Healthcare, 2009. Vol. 26, no 1, p. 48-56
Keywords [en]
pediatric, leukemia, prognostic, biomarker
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:mau:diva-5329DOI: 10.1080/08880010802625530ISI: 000263269000005PubMedID: 19206008Scopus ID: 2-s2.0-61649117545Local ID: 9228OAI: oai:DiVA.org:mau-5329DiVA, id: diva2:1402184
2020-02-282020-02-282025-09-17Bibliographically approved