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Tobacco and surgery: the Swedish Tobacco Cohort
Malmö University, Faculty of Odontology (OD).ORCID iD: 0009-0004-7759-4342
2026 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Cigarette smoking is a well-established risk factor for postoperative complications, and preoperative smoking cessation is recommended before medical surgery. However, evidence regarding oral surgical procedures is limited, and the effects of snus, a smokeless tobacco product widely used in Sweden, on surgical outcomes remain largely unknown. The overall aim of this thesis was to address knowledge gaps regarding tobacco use and postoperative complications, with particular focus on snus. Specifically, the thesis aimed to (1) evaluate the evidence for preoperative smoking cessation in oral surgery, (2) establish a population-based cohort for studying tobacco-related health outcomes, and (3) investigate associations between snus use and postoperative complications following dental and gastrointestinal surgery. Study I was a systematic review of preoperative smoking cessation in oral surgery. Studies II–IV used a registry-based approach. Study II describes the creation of the Swedish Tobacco Cohort (SWETOC), linking tobacco exposure data from the Swedish Public Dental Service (approximately 5.5 million individuals, 1994–2023) to national health registers. Studies III and IV used SWETOC and national health registers to examine associations between snus use and postoperative complications after dental surgery (n=392,241 procedures) and gastrointestinal surgery (n=48,874 procedures), respectively, using multivariable logistic regression. The systematic review found insufficient evidence to determine the effect of preoperative smoking cessation in oral surgery. In Study III, snus use was associated with increased antibiotic prescriptions following dental surgery among women (OR 1.17, 95% CI 1.05–1.31), but not among men. As antibiotics are typically prescribed to treat or prevent infection, this finding suggests that female snus users may experience higher rates of postoperative infectious complications. In Study IV, snus use among never smokers was associated with modestly elevated risks of postoperative complications and readmission following gastrointestinal surgery, predominantly observed among men, and an increased risk of pneumonia (OR 3.09, 95% CI 1.04–7.29) compared to never tobacco users. However, the pneumonia finding should be interpreted with caution given the small number of events (n=46), as reflected by the wide confidence interval that only marginally excludes the null. Taken together, these findings suggest that the perioperative risks associated with tobacco exposure may extend beyond smoking to include smokeless tobacco products, though further research is needed to confirm these associations and clarify the mechanisms involved, including the reasons for the observed sex differences in dental surgery. This thesis illustrates how SWETOC can contribute to tobacco research and adds to emerging evidence that snus use may be associated with perioperative risks.

Place, publisher, year, edition, pages
Malmö: Malmö University Press, 2026. , p. 101
Series
Malmö University Odontological Dissertations, ISSN 1650-6065, E-ISSN 2004-9307
National Category
Odontology
Identifiers
URN: urn:nbn:se:mau:diva-81876DOI: 10.24834/isbn.9789178776481ISBN: 9789178776474 (print)ISBN: 9789178776481 (electronic)OAI: oai:DiVA.org:mau-81876DiVA, id: diva2:2029347
Public defence
2026-02-13, Faculty of Odontology, Malmö University, Malmö, 09:15
Opponent
Supervisors
Note

Paper 2 and 3 in dissertation as manuscript, not included in the full text online.

Available from: 2026-01-16 Created: 2026-01-16 Last updated: 2026-01-21Bibliographically approved
List of papers
1. Does smoking cessation affect postoperative healing following oral surgery among smokers? - a systematic review.
Open this publication in new window or tab >>Does smoking cessation affect postoperative healing following oral surgery among smokers? - a systematic review.
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2024 (English)In: BMC Oral Health, E-ISSN 1472-6831, Vol. 24, no 1, article id 242Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: It is well documented that smokers suffer increased risk of postoperative complications after medical surgery, for example delayed healing and increased risk of infection. It is also known that preoperative smoking cessation can reduce the risk of these complications. Because of this there are guidelines regarding preoperative smoking cessation in non-oral medical surgery. There are however no specific guidelines regarding oral surgical procedures, such as surgical extractions, dentoalveolar surgery, periodontal surgery, or dental implantation. Nevertheless, it is common that dentists and oral surgeons recommend smoking cessation pre to oral surgical procedures. The aim with this systematic review was to see if there are any evidence in the literature, supporting preoperative smoking cessation in oral surgical procedures.

METHODS: A systematic search of the electronic databases PubMed, Scopus, Web of Science, and Cochrane was conducted to identify studies addressing the effect of preoperative smoking cessation in oral surgical procedures. Included publications were subjected to preidentified inclusion criterion. Six examiners performed the eligibility and quality assessment of relevant studies. Risk of bias was assessed using ROBINS-I and RoB 2. Certainty assessment was carried out using GRADE.

RESULTS: The initial search resulted in 2255 records, and after removal of 148 duplicates, 16 articles met an acceptable level of relevance. These were read in full text, whereof 12 articles were excluded, due to different intervention, outcome, or study design than stated in the review protocol. One study remained with moderate risk of bias and three were excluded due to high risk of bias.

CONCLUSION: This systematic review could not determine the effect of smoking cessation pre to oral surgical procedures, in smokers. This indicates lack of knowledge in the effects of smoking cessation. We also conclude a lack of knowledge in how to design smoking cessation in the most effective way.

Place, publisher, year, edition, pages
BioMed Central (BMC), 2024
Keywords
Complication, Guideline, Healing, Oral surgery, Smoking cessation
National Category
Dentistry
Identifiers
urn:nbn:se:mau:diva-66276 (URN)10.1186/s12903-024-03989-1 (DOI)001163308000005 ()38360627 (PubMedID)2-s2.0-85185237907 (Scopus ID)
Available from: 2024-03-08 Created: 2024-03-08 Last updated: 2026-01-16Bibliographically approved
2. A nation-wide study on snus and smoked tobacco: The Swedish Tobacco Cohort (SWETOC)
Open this publication in new window or tab >>A nation-wide study on snus and smoked tobacco: The Swedish Tobacco Cohort (SWETOC)
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2025 (English)In: Scandinavian Journal of Public Health, ISSN 1403-4948, E-ISSN 1651-1905, article id 14034948251350193Article in journal (Refereed) Epub ahead of print
Abstract [en]

Aims: Smoking increases the risk of developing severe diseases. However, the effects of snus are less known. We aimed to create a cohort on tobacco exposure by collecting data from the Swedish Public Dental Service. The cohort will be used to study even rare health outcomes of both smoking and snus.

Methods: In Sweden, 35% (2021) of the adult population and 85% (2021) of all children use the Public Dental Service. The dental practitioner asks about tobacco use and registers replies in patients’ records. We have now assembled a database of all available such data in the country and linked them to other national health and social registers, forming the Swedish Tobacco Cohort (SWETOC). SWETOC is hence a cohort with prospectively designed data collection.

Results: Out of all 21 regions in Sweden, 19 participated, and approximately 5.5 million unique individuals provided tobacco data. Registrations dated from 1994 to 2023. All participating regions provided data from at least 2015 and forward. Overall prevalence for smoking was 12%, and 13% for snus. More men used snus than women, and there were regional differences in tobacco use patterns. Gender distribution was around equal at all age levels. Some regions provided additional tobacco information such as amount and type of product used, willingness for tobacco cessation, and notes in free text.

Conclusions: SWETOC is a novel resource that can be used to close the current and future knowledge gaps regarding the health outcomes of smoked and smokeless tobacco.

Place, publisher, year, edition, pages
SAGE Publications, 2025
Keywords
cohort, health, lifestyle, nicotine, Smoking, snuff, snus, Sweden, SWETOC, tobacco
National Category
Public Health, Global Health and Social Medicine
Identifiers
urn:nbn:se:mau:diva-78819 (URN)10.1177/14034948251350193 (DOI)001514581000001 ()40557757 (PubMedID)2-s2.0-105010358819 (Scopus ID)
Funder
Swedish Research CouncilSwedish Research Council
Available from: 2025-08-11 Created: 2025-08-11 Last updated: 2026-01-16Bibliographically approved
3. Snus and recovery after oral surgery: The Swedish Tobacco Cohort (SWETOC)
Open this publication in new window or tab >>Snus and recovery after oral surgery: The Swedish Tobacco Cohort (SWETOC)
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(English)Manuscript (preprint) (Other academic)
National Category
Odontology
Identifiers
urn:nbn:se:mau:diva-81877 (URN)
Available from: 2026-01-16 Created: 2026-01-16 Last updated: 2026-02-06Bibliographically approved
4. Snus use and risk of complications and death in resectional gastrointestinal surgery patients
Open this publication in new window or tab >>Snus use and risk of complications and death in resectional gastrointestinal surgery patients
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(English)Manuscript (preprint) (Other academic)
National Category
Odontology
Identifiers
urn:nbn:se:mau:diva-81880 (URN)
Available from: 2026-01-16 Created: 2026-01-16 Last updated: 2026-01-16Bibliographically approved

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