Person-centered care (PCC) emphasizes seeing patients as individuals with unique needs, values, and preferences. In anesthesia care, PCC is challenged by the fact that patients are unconscious for most of the perioperative process. This study aimed to illuminate nurse anesthetists’ (NA:s’) perspectives on person-centered anesthesia care. A qualitative design was used, and twelve NA:s from three hospitals in southern Sweden were interviewed. Data were analysed using inductive content analysis. The analysis resulted in three main categories: establishing a trusting relationship, assuming responsibility for the patient’s needs and between production pressure and person-centered care. Within establishing a trusting relationship, NA:s described the brief preoperative encounter as crucial for establishing trust and forming the basis for PCC during anesthesia. Adequate preparation and access to patient information were viewed as essential for anticipating individual needs. The category assuming responsibility for the patient’s needs illustrated how NA:s safeguarded patients’ physical, psychosocial, and relational needs, acted as patient advocates and adapted anesthesia care to individual preferences. The category between production pressure and person-centered care highlighted organisational and interprofessional challenges, including production pressures, time constraints, and limited discussion of PCC within teams. NA:s expressed a need for education, structured dialogue, and organisational support to strengthen PCC in anesthesia care. The findings underscore the importance of trust, preparation, and organisational commitment in enabling person-centered anesthesia practice.