The maxillofacial region is important, with vital functions such as breathing, eating, talking, smelling, and vision. Moreover, it is also an aesthetically important region. Injuries to the maxillofacial region may, therefore, have profound consequences for the individual's quality of life. Earlier used methods of conservative treatment of maxillofacial fractures with suspension wires and intermaxillary fixation have been replaced by methods aiming at exposing fracture lines, allowing precise alignment and application of osteosynthesis hardware, and enabling a faster return to function. This chapter aims to give an overview of modern treatment principles in the management of fractures of the midface and the upper face by describing surgical approaches, techniques, and strategies for fracture treatment. A section on biodegradable osteosynthesis material is also presented.