Investigating antibacterial and anti-inflammatory properties of synthetic curcuminoidsShow others and affiliations
2024 (English)In: Frontiers in Medicine, E-ISSN 2296-858X, Vol. 11, article id 1478122Article in journal (Refereed) Published
Abstract [en]
The concept of intratumoral microbiota is gaining attention in current research. Tumor-associated microbiota can activate oncogenic signaling pathways such as NF-kappa B, thereby promoting tumor development and progression. Numerous studies have demonstrated that curcumin and its analogs possess strong antitumor effects by targeting the NF-kappa B signaling pathway, along with potent antibacterial properties. In this study, we tested the antibacterial activity of two curcuminoids, Py-cPen and V-cPen, against the Gram-negative bacterial strains Pseudomonas aeruginosa and Escherichia coli and the Gram-positive bacterial strain Streptococcus aureus using in vitro assays and fluorescent microscopy. We observed that both Py-cPen and V-cPen reduced NF-kappa B activation upon lipopolysacharide (LPS) challenge in cell assays. In addition, our findings indicate that Py-cPen and V-cPen interact with LPS, as demonstrated by transmission electron microscopy and confirmed using in silico analyses, thereby modulating LPS activity. Overall, our data indicate that Py-cPen and V-cPen exhibit strong antibacterial and antiinflammatory properties, suggesting their potential as candidates for new multitarget therapeutic strategies.
Place, publisher, year, edition, pages
Frontiers Media S.A., 2024. Vol. 11, article id 1478122
Keywords [en]
curcuminoids, antibacterial, anti-inflammatory, immunomodulatory, lipopolysaccharide
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:mau:diva-72352DOI: 10.3389/fmed.2024.1478122ISI: 001352016800001PubMedID: 39534226Scopus ID: 2-s2.0-85208788038OAI: oai:DiVA.org:mau-72352DiVA, id: diva2:1915565
2024-11-232024-11-232024-11-23Bibliographically approved