Multi-modal investigation of the bone micro- and ultrastructure, and elemental distribution in the presence of Mg-xGd screws at mid-term healing stagesHelmholtz Zent Hereon, Inst Mat Physiscs, Geesthacht, Germany.
Deutsch Elektronen Synchrotron DESY, Hamburg, Germany.
Helmholtz Zent Hereon, Inst Coastal Environm Chem, Geesthacht, Germany.
Univ Kiel, Mol Imaging North Competence Ctr, Kiel, Germany.
UKSH, Dept Oral & Maxillofacial Surg Campus Kiel, Kiel, Germany.
Univ Kiel, Mol Imaging North Competence Ctr, Kiel, Germany.
Helmholtz Zent Hereon, Inst Met Biomat, Geesthacht, Germany.
Michigan Technol Univ, Dept Biomed Engn, Houghton, MI USA.
Michigan Technol Univ, Dept Biomed Engn, Houghton, MI USA.
Helmholtz Zent Hereon, Inst Mat Mech, Geesthacht, Germany.
Helmholtz Zent Hereon, Inst Mat Physiscs, Geesthacht, Germany.
Helmholtz Zent Hereon, Inst Mat Physiscs, Geesthacht, Germany.
Michigan State Univ, Dept Microbiol & Biochem, E Lansing, MI USA.
Med Coll Wisconsin, Joint Dept Biomed Engn, Milwaukee, WI USA.
Helmholtz Zent Hereon, Inst Met Biomat, Geesthacht, Germany; Helmholtz Zent Hereon, Inst Coastal Environm Chem, Geesthacht, Germany.
Helmholtz Zent Hereon, Inst Met Biomat, Geesthacht, Germany.
Helmholtz Zent Hereon, Inst Met Biomat, Geesthacht, Germany.
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2024 (English)In: BIOACTIVE MATERIALS, ISSN 2452-199X, Vol. 41, p. 657-671Article in journal (Refereed) Published
Abstract [en]
Magnesium (Mg) - based alloys are becoming attractive materials for medical applications as temporary bone implants for support of fracture healing, e.g. as a suture anchor. Due to their mechanical properties and biocompatibility, they may replace titanium or stainless-steel implants, commonly used in orthopedic field. Nevertheless, patient safety has to be assured by finding a long-term balance between metal degradation, osseointegration, bone ultrastructure adaptation and element distribution in organs. In order to determine the implant behavior and its influence on bone and tissues, we investigated two Mg alloys with gadolinium contents of 5 and 10 wt percent in comparison to permanent materials titanium and polyether ether ketone. The implants were present in rat tibia for 10, 20 and 32 weeks before sacrifice of the animal. Synchrotron radiation-based micro computed tomography enables the distinction of features like residual metal, degradation layer and bone structure. Additionally, X-ray diffraction and X-ray fluorescence yield information on parameters describing the bone ultrastructure and elemental composition at the bone-to-implant interface. Finally, with element specific mass spectrometry, the elements and their accumulation in the main organs and tissues are traced. The results show that Mg-xGd implants degrade in vivo under the formation of a stable degradation layer with bone remodeling similar to that of Ti after 10 weeks. No accumulation of Mg and Gd was observed in selected organs, except for the interfacial bone after 8 months of healing. Thus, we confirm that Mg-5Gd and Mg-10Gd are suitable material choices for bone implants.
Place, publisher, year, edition, pages
Elsevier, 2024. Vol. 41, p. 657-671
Keywords [en]
Biodegradable implants, Bone ultrastructure, Degradation, Mg-based alloys
National Category
Biomaterials Science
Identifiers
URN: urn:nbn:se:mau:diva-71670DOI: 10.1016/j.bioactmat.2024.07.019ISI: 001318289300001PubMedID: 39296873Scopus ID: 2-s2.0-85202285582OAI: oai:DiVA.org:mau-71670DiVA, id: diva2:1907377
2024-10-222024-10-222024-10-28Bibliographically approved