Malmö University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Bisphosphonates and Dental Implants: A Systematic Review and Meta-Analysis
Malmö University, Faculty of Odontology (OD).
Malmö University, Faculty of Odontology (OD).
Malmö University, Faculty of Odontology (OD).ORCID iD: 0000-0002-3460-3374
2023 (English)In: Materials, E-ISSN 1996-1944, Vol. 16, no 18, article id 6078Article, review/survey (Refereed) Published
Abstract [en]

The purpose of the present systematic review was to investigate the influence of bisphosphonates (BPs) on the dental implant failure rate and marginal bone loss (MBL). An electronic search was undertaken in three databases, plus a manual search of journals. Meta-analyses were performed, besides a meta-regression in order to verify how the log odds ratio (OR) was associated with follow-up time. The five- and ten-year estimated implant survivals were calculated. The review included 33 publications. Altogether, there were 1727 and 21,986 implants placed in patients taking and not taking BPs, respectively. A pairwise meta-analysis (26 studies) showed that implants in BP patients had a higher failure risk in comparison to non-BP patients (OR 1.653, p = 0.047). There was an estimated decrease of 0.004 in log OR for every additional month of follow-up, although it was not significant (p = 0.259). The global estimated implant survival in patients taking BPs after 5 and 10 years was 94.2% (95% CI, 94.0-94.4) and 90.1% (95% CI, 89.8-90.3), respectively. It was not possible to make any reliable analysis concerning MBL, as only two studies reported MBL results separated by groups. There is a 65.3% higher risk of implant failure in patients taking BPs in comparison to patients not taking this class of drugs.

Place, publisher, year, edition, pages
MDPI, 2023. Vol. 16, no 18, article id 6078
Keywords [en]
dental implants, bisphosphonates, implant failure, marginal bone loss, systematic review, meta-analysis
National Category
Dentistry
Identifiers
URN: urn:nbn:se:mau:diva-63028DOI: 10.3390/ma16186078ISI: 001073899400001PubMedID: 37763356Scopus ID: 2-s2.0-85173051085OAI: oai:DiVA.org:mau-63028DiVA, id: diva2:1803533
Available from: 2023-10-09 Created: 2023-10-09 Last updated: 2024-07-04Bibliographically approved

Open Access in DiVA

fulltext(1827 kB)106 downloads
File information
File name FULLTEXT01.pdfFile size 1827 kBChecksum SHA-512
66f0436bdf68176c581844840d4523a1079a112d1e1503c0ed89558b63d52db09f7ae809ec7d1f877a28c8c59d25f371c9d2c9422de986ca406b38496b8a1934
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMedScopus

Authority records

Chrcanovic, Bruno Ramos

Search in DiVA

By author/editor
Chrcanovic, Bruno Ramos
By organisation
Faculty of Odontology (OD)
In the same journal
Materials
Dentistry

Search outside of DiVA

GoogleGoogle Scholar
Total: 107 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 260 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf