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Plasma circulating cell-free mitochondrial DNA in social anxiety disorder
Department of Clinical Sciences Lund, Psychiatry, Faculty of Medicine, Lund University, Lund, Sweden; Office for Psychiatry and Habilitation, Psychiatry Research Skåne, Lund, Sweden.
Department of Psychology, Uppsala University, Uppsala, Sweden.
Department of Molecular Medicine and Surgery, Karolinska Institutet, and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
Malmö University, Faculty of Health and Society (HS), Department of Biomedical Science (BMV).
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2022 (English)In: Psychoneuroendocrinology, ISSN 0306-4530, E-ISSN 1873-3360, Vol. 148, article id 106001Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: To investigate plasma levels of circulating cell-free mitochondrial DNA (ccf-mtDNA) in patients with social anxiety disorder (SAD) and healthy controls (HC).

METHODS: In this study, 88 participants (46 patients with SAD and 42 HCs) were enrolled and both ccf-mtDNA and peripheral blood mononuclear cells (PBMC) mtDNA copy number (mtDNA-cn) were measured at up to three times per individual (9-11 weeks apart). SAD patients also received cognitive behavioral therapy (CBT) between the second and third time-point.

RESULTS: SAD patients had significantly lower ccf-mtDNA compared to HCs at all time points, but ccf-mtDNA did not change significantly after CBT, and was not associated with severity of anxiety symptoms. Plasma ccf-mtDNA did not significantly correlate with PBMC mtDNA-cn in patients.

CONCLUSION: This is the first report of lower ccf-mtDNA in patients with an anxiety disorder. Our findings could reflect a more chronic illness course in SAD patients with prolonged periods of psychological stress leading to decreased levels of ccf-mtDNA, but future longitudinal studies are needed to confirm or refute this hypothesis.

Place, publisher, year, edition, pages
Elsevier, 2022. Vol. 148, article id 106001
Keywords [en]
Circulating cell-free mitochondrial DNA, Cognitive behavioural therapy, Social anxiety disorder
National Category
Psychiatry
Identifiers
URN: urn:nbn:se:mau:diva-56603DOI: 10.1016/j.psyneuen.2022.106001ISI: 000918010400006PubMedID: 36508952Scopus ID: 2-s2.0-85143981831OAI: oai:DiVA.org:mau-56603DiVA, id: diva2:1718508
Available from: 2022-12-13 Created: 2022-12-13 Last updated: 2024-02-05Bibliographically approved

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Ohlsson, Lars

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