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Reversible Self-Assembled Monolayers with Tunable Surface Dynamics for Controlling Cell Adhesion Behavior.
Malmö University, Faculty of Health and Society (HS), Department of Biomedical Science (BMV). Malmö University, Biofilms Research Center for Biointerfaces.
Malmö University, Faculty of Health and Society (HS), Department of Biomedical Science (BMV). Malmö University, Biofilms Research Center for Biointerfaces.
Malmö University, Faculty of Health and Society (HS), Department of Biomedical Science (BMV). Malmö University, Biofilms Research Center for Biointerfaces. Institute for Advanced Materials, School of Materials Science and Engineering, Jiangsu University, Zhenjiang, Jiangsu 212 013, China.
Department of Physics and Astronomy, University of Western Ontario, 1151 Richmond Street, London, Ontario, Canada N6A 3K7.
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2022 (English)In: ACS Applied Materials and Interfaces, ISSN 1944-8244, E-ISSN 1944-8252, Vol. 14, no 37, p. 41790-41799Article in journal (Refereed) Published
Abstract [en]

Cells adhering onto surfaces sense and respond to chemical and physical surface features. The control over cell adhesion behavior influences cell migration, proliferation, and differentiation, which are important considerations in biomaterial design for cell culture, tissue engineering, and regenerative medicine. Here, we report on a supramolecular-based approach to prepare reversible self-assembled monolayers (rSAMs) with tunable lateral mobility and dynamic control over surface composition to regulate cell adhesion behavior. These layers were prepared by incubating oxoacid-terminated thiol SAMs on gold in a pH 8 HEPES buffer solution containing different mole fractions of ω-(ethylene glycol)2-4- and ω-(GRGDS)-, α-benzamidino bolaamphiphiles. Cell shape and morphology were influenced by the strength of the interactions between the amidine-functionalized amphiphiles and the oxoacid of the underlying SAMs. Dynamic control over surface composition, achieved by the addition of inert filler amphiphiles to the RGD-functionalized rSAMs, reversed the cell adhesion process. In summary, rSAMs featuring mobile bioactive ligands offer unique capabilities to influence and control cell adhesion behavior, suggesting a broad use in biomaterial design, tissue engineering, and regenerative medicine.

Place, publisher, year, edition, pages
American Chemical Society (ACS), 2022. Vol. 14, no 37, p. 41790-41799
Keywords [en]
ECM mimic, cell modulation, dynamic multivalency, reversible cell adhesion, supported lipid bilayer
National Category
Other Materials Engineering
Identifiers
URN: urn:nbn:se:mau:diva-55183DOI: 10.1021/acsami.2c12029ISI: 000856045900001PubMedID: 36074978Scopus ID: 2-s2.0-85138080666OAI: oai:DiVA.org:mau-55183DiVA, id: diva2:1699184
Available from: 2022-09-27 Created: 2022-09-27 Last updated: 2024-02-05Bibliographically approved
In thesis
1. Stimuli-responsive lipid bilayer mimics for protein, virus and cell recognition
Open this publication in new window or tab >>Stimuli-responsive lipid bilayer mimics for protein, virus and cell recognition
2018 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The most well-studied two-dimensional biomimetic cellular membrane modelsare self-assembled monolayers (SAMs) and supported lipid bilayers (SLBs).The former has the advantage of control over ligand density, homogeneity andorientation, allowing unambiguous interaction studies. It however lacks longrangelateral mobility, which is one of the most important aspects of cellularmembranes. SLBs are laterally mobile but they are fragile and instable uponexposure to air. Literature examples that contain all the above desirablecharacteristics with stimuli-responsiveness to fabricate biomaterials forbiosensing or modulating cell adhesion are rare. We here report on anadaptable platform, reversible self-assembled monolayers (rSAMs), featuringstrongly enhanced affinity towards influenza viruses as compared to SAMs,lateral mobility to investigate glycan-lectin interactions and tunable surfacedynamics to modulate cell adhesion. This new system utilizes noncovalentamidinium-carboxylate ion pairs for building up stable and ordered twodimensionalassemblies, akin to lipid bilayers but with a simple preparationprocess, stimuli-responsiveness and fast on/off rates.

Place, publisher, year, edition, pages
Malmö university, Faculty of Health and Society, 2018. p. 68
Series
Malmö University Health and Society Dissertations, ISSN 1653-5383 ; 7
Keywords
Lipid bilayers, Adaptable, Self-assembled, Monolayers, Supramolecular chemistry, Cell adhesion, Biocensor
National Category
Natural Sciences
Identifiers
urn:nbn:se:mau:diva-7321 (URN)10.24834/2043/24967 (DOI)24967 (Local ID)9789171049261 (ISBN)9789171049278 (ISBN)24967 (Archive number)24967 (OAI)
Note

Note: The papers are not included in the fulltext online.

Paper II and IV in dissertation as manuscript, paper II with title "pH-switchable lipid bilayer-like monolayers with ultrahigh lectin affinity", paper IV with title "Reversible self-assembled monolayers (rSAMs) with tunable surface dynamics modulate cell adhesion behaviour"

Available from: 2020-02-28 Created: 2020-02-28 Last updated: 2024-03-18Bibliographically approved

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Yeung, Sing YeeSergeeva, YuliaPan, GuoqingEl-Schich, ZahraGjörloff Wingren, AnetteStollenwerk, Maria MSellergren, Börje

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