Multimodal ex vivo methods reveal that Gd-rich corrosion byproducts remain at the implant site of biodegradable Mg-Gd screwsShow others and affiliations
2021 (English)In: Acta Biomaterialia, ISSN 1742-7061, E-ISSN 1878-7568, Vol. 136, p. 582-591Article in journal (Refereed) Published
Abstract [en]
Extensive research is being conducted on magnesium (Mg) alloys for bone implant manufacturing, due to their biocompatibility, biodegradability and mechanical properties. Gadolinium (Gd) is among the most promising alloying elements for property control in Mg alloy implants; however, its toxicity is controversial. Investigating Gd behavior during implant corrosion is thus of utmost importance. In this study, we analyzed the degradation byproducts at the implant site of biodegradable Mg-5Gd and Mg-10Gd implants after 12 weeks healing time, using a combination of different imaging techniques: histology, energy-dispersive x-ray spectroscopy (EDX), x-ray microcomputed tomography (µCT) and neutron µCT. The main finding has been that, at the healing time in exam, the corrosion appears to have involved only the Mg component, which has been substituted by calcium and phosphorus, while the Gd remains localized at the implant site. This was observed in 2D by means of EDX maps and extended to 3D with a novel application of neutron tomography. X-ray fluorescence analysis of the main excretory organs also did not reveal any measurable accumulation of Gd, further reinforcing the conclusion that very limited or no removal at all of Gd-alloy happened during degradation.
Place, publisher, year, edition, pages
Elsevier, 2021. Vol. 136, p. 582-591
Keywords [en]
Molecular Biology, Biomedical Engineering, Biochemistry, Biomaterials, General Medicine, Biotechnology
National Category
Biomaterials Science Dentistry Orthopaedics
Research subject
Health and society studies
Identifiers
URN: urn:nbn:se:mau:diva-46879DOI: 10.1016/j.actbio.2021.09.047ISI: 000723158500003PubMedID: 34601107Scopus ID: 2-s2.0-85116896974OAI: oai:DiVA.org:mau-46879DiVA, id: diva2:1612079
Funder
Swedish Research Council2021-11-172021-11-172025-10-09Bibliographically approved