Malmö University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Multimodal ex vivo methods reveal that Gd-rich corrosion byproducts remain at the implant site of biodegradable Mg-Gd screws
Lund University.ORCID iD: 0000-0002-2929-4247
Malmö University, Faculty of Odontology (OD). Malmö University, Biofilms Research Centre for Biointerfaces (BRCB).ORCID iD: 0000-0001-7488-3588
Helmholtz-Zentrum hereon GmbH, Germany.ORCID iD: 0000-0001-6457-3607
Helmholtz Centre for Materials and Energy, Germany.
Show others and affiliations
2021 (English)In: Acta Biomaterialia, ISSN 1742-7061, E-ISSN 1878-7568, Vol. 136, p. 582-591Article in journal (Refereed) Published
Abstract [en]

Extensive research is being conducted on magnesium (Mg) alloys for bone implant manufacturing, due to their biocompatibility, biodegradability and mechanical properties. Gadolinium (Gd) is among the most promising alloying elements for property control in Mg alloy implants; however, its toxicity is controversial. Investigating Gd behavior during implant corrosion is thus of utmost importance. In this study, we analyzed the degradation byproducts at the implant site of biodegradable Mg-5Gd and Mg-10Gd implants after 12 weeks healing time, using a combination of different imaging techniques: histology, energy-dispersive x-ray spectroscopy (EDX), x-ray microcomputed tomography (µCT) and neutron µCT. The main finding has been that, at the healing time in exam, the corrosion appears to have involved only the Mg component, which has been substituted by calcium and phosphorus, while the Gd remains localized at the implant site. This was observed in 2D by means of EDX maps and extended to 3D with a novel application of neutron tomography. X-ray fluorescence analysis of the main excretory organs also did not reveal any measurable accumulation of Gd, further reinforcing the conclusion that very limited or no removal at all of Gd-alloy happened during degradation.

Place, publisher, year, edition, pages
Elsevier, 2021. Vol. 136, p. 582-591
Keywords [en]
Molecular Biology, Biomedical Engineering, Biochemistry, Biomaterials, General Medicine, Biotechnology
National Category
Biomaterials Science Dentistry Orthopaedics
Research subject
Health and society studies
Identifiers
URN: urn:nbn:se:mau:diva-46879DOI: 10.1016/j.actbio.2021.09.047ISI: 000723158500003PubMedID: 34601107Scopus ID: 2-s2.0-85116896974OAI: oai:DiVA.org:mau-46879DiVA, id: diva2:1612079
Funder
Swedish Research CouncilAvailable from: 2021-11-17 Created: 2021-11-17 Last updated: 2025-10-09Bibliographically approved

Open Access in DiVA

fulltext(2683 kB)230 downloads
File information
File name FULLTEXT01.pdfFile size 2683 kBChecksum SHA-512
d426d7081a8f64255d493ed3c0cba3c2302753c5095bfb0f6d396a5443272dcf366a0617d30159e7210c91d9d71608d3d3544a493b41ca312f64786fb7b700bf
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMedScopus

Authority records

Galli, SilviaPrgomet, ZdenkaWennerberg, Ann

Search in DiVA

By author/editor
Peruzzi, NiccolòGalli, SilviaHelmholz, HeikeOrlov, DmytroPrgomet, ZdenkaWennerberg, AnnBech, Martin
By organisation
Faculty of Odontology (OD)Biofilms Research Centre for Biointerfaces (BRCB)
In the same journal
Acta Biomaterialia
Biomaterials ScienceDentistryOrthopaedics

Search outside of DiVA

GoogleGoogle Scholar
Total: 232 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 118 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf