Malmö University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Hormonal and stress-related effects in men aged 25-35, from daily intake of Lactobacillus probiotic dietary supplements
Malmö University, Faculty of Health and Society (HS), Department of Biomedical Science (BMV).
2021 (English)Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

Background: There is a bidirectional communication system between the gut-microbiota and the brain. Probiotics are live microorganisms that should have health benefits on the host. Modulations of the gut-microbiota using probiotics to target inflammation, stress and depression have shown promising results in rodent studies and are now to be proven in human subjects. 

Method: 20 male participants aged 25-35, were aliquoted into three groups. All groups consumed placebo tablets for two weeks. For additionally six weeks, two of the groups were administered different commercially available probiotic tablets containing Lactobacillus reuteri and the last group continued the placebo tablets. Venous blood samples and a questionnaire about general wellbeing were collected at baseline, after two weeks, and at the end of the eight weeks study. Cortisol was analysed by electrochemiluminescence immunoassay (ECLIA). An enzymatic colorimetric test was used to determine glucose concentrations (GOD-PAP). Soluble urokinase plasminogen activator receptor (suPAR) concentrations determined with ELISA. Oxidative stress was carried out using Free Oxygen Radicals Testing (FORT).

Results: For all biomarkers no significant differences were found (p>0.05). For the questionnaires, a significant difference was found in the placebo group. Here, a general wellbeing improved throughout the study. 

Conclusion: The present study was affected by the COVID-19 pandemic, which led to a decrease in number of participants, change of environment and sampling at different times of the day which could have had an impact on diurnal variation. Although none of the biomarkers showed statistically significant results, further investigations of Lactobacillus reuteri in human subjects are necessary. In addition, this study highlights the importance of developing a robust model for translating findings in rodent studies to healthy human subjects.

Place, publisher, year, edition, pages
2021. , p. 25
Keywords [en]
Cortisol, inflammation, Lactobacillus reuteri, microbiota, probiotic, stress
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
URN: urn:nbn:se:mau:diva-43491OAI: oai:DiVA.org:mau-43491DiVA, id: diva2:1566385
Educational program
HS Biomedical Surface Science
Supervisors
Examiners
Available from: 2021-06-15 Created: 2021-06-15 Last updated: 2021-06-15Bibliographically approved

Open Access in DiVA

No full text in DiVA

Search in DiVA

By author/editor
Bertelsen, Sissel Asser
By organisation
Department of Biomedical Science (BMV)
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)

Search outside of DiVA

GoogleGoogle Scholar

urn-nbn

Altmetric score

urn-nbn
Total: 126 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf