As people with disabilities often face difficulties entering the labour market, entrepreneurship and self-employment are often regarded as an opportunity to gain employment and earn a living. This article presents a scoping review that aims to investigate what establishment motives previous studies have identified for self-employment and entrepreneurship among people with disabilities. Four themes emerged: economic motives; flexibility and self-determination; avoiding discrimination; and personal development and being able to contribute something. In the article we discuss the results and relate them to the general discourse on entrepreneurship, which often includes the concept of autonomy. We argue that the findings suggest implications for how to develop support and strategies for this group, to help them avoid ending up in an even more vulnerable position. In this work, the individual’s own motives for establishment are of great value.