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Exploring biomarkers associated with deteriorating vascular health using a targeted proteomics chip: The SABPA study
Malmö University, Faculty of Health and Society (HS), Department of Biomedical Science (BMV). Malmö University, Biofilms Research Center for Biointerfaces. Lund University.
Hypertension in Africa Research Team (HART).
Hypertension in Africa Research Team (HART); MRC Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa.
Hypertension in Africa Research Team (HART); MRC Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa.
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2021 (English)In: Medicine, ISSN 0025-7974, E-ISSN 1536-5964, Vol. 100, no 20, article id e25936Article in journal (Refereed) Published
Abstract [en]

ABSTRACT: In this observational study, by the use of a multiplex proteomic platform, we aimed to explore associations between 92 targeted proteins involved in cardiovascular disease and/or inflammation, and phenotypes of deteriorating vascular health, with regards to ethnicity.Proteomic profiling (92 proteins) was carried out in 362 participants from the Sympathetic activity and Ambulatory Blood Pressure in Africans (SABPA) study of black and white African school teachers (mean age 44.7 ± 9.9 years, 51.9% women, 44.5% Black Africans, 9.9% with known cardiovascular disease). Three proteins with <15% of samples below detectable limits were excluded from analyses. Associations between multiple proteins and prevalence of hypertension as well as vascular health [Carotid intima-media thickness (cIMT) and pulse wave velocity (PWV)] measures were explored using Bonferroni-corrected regression models.Bonferroni-corrected significant associations between 89 proteins and vascular health markers were further adjusted for clinically relevant co-variates. Hypertension was associated with growth differentiation factor 15 (GDF-15) and C-X-C motif chemokine 16 (CXCL16). cIMT was associated with carboxypeptidase A1 (CPA1), C-C motif chemokine 15 (CCL15), chitinase-3-like protein 1 (CHI3L1), scavenger receptor cysteine-rich type 1 protein M130 (CD163) and osteoprotegerin, whereas PWV was associated with GDF15, E-selectin, CPA1, fatty acid-binding protein 4 (FABP4), CXCL16, carboxypeptidase B (CPB1), and tissue-type plasminogen activator. Upon entering ethnicity into the models, the associations between PWV and CPA1, CPB1, GDF-15, FABP4, CXCL16, and between cIMT and CCL-15, remained significant.Using a multiplex proteomic approach, we linked phenotypes of vascular health with several proteins. Novel associations were found between hypertension, PWV or cIMT and proteins linked to inflammatory response, chemotaxis, coagulation or proteolysis. Further, we could reveal whether the associations were ethnicity-dependent or not.

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2021. Vol. 100, no 20, article id e25936
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Cardiac and Cardiovascular Systems
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URN: urn:nbn:se:mau:diva-42494DOI: 10.1097/MD.0000000000025936ISI: 000658953300050PubMedID: 34011069Scopus ID: 2-s2.0-85106603646OAI: oai:DiVA.org:mau-42494DiVA, id: diva2:1558729
Available from: 2021-05-31 Created: 2021-05-31 Last updated: 2024-02-05Bibliographically approved

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Dieden, AnnaGudmundsson, Petri

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