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Can mesoporous nanoparticles promote bioavailability of topical pharmaceutics?
Malmö University, Faculty of Health and Society (HS), Department of Biomedical Science (BMV). Malmö University, Biofilms Research Center for Biointerfaces. Nanologica AB.ORCID iD: 0000-0002-2535-7108
University of Gothenburg.
Istituto per la Sintesi Organica e la Fotoreattività, Italy.
Malmö University, Faculty of Health and Society (HS), Department of Biomedical Science (BMV). Malmö University, Biofilms Research Center for Biointerfaces.
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2021 (English)In: International Journal of Pharmaceutics, ISSN 0378-5173, E-ISSN 1873-3476, Vol. 602, article id 120609Article in journal (Refereed) Published
Abstract [en]

When applied to skin, particulate matter has been shown to accumulate in hair follicles. In addition to follicles, the skin topography also incorporates trench-like furrows where particles potentially can accumulate; however, the furrows have not been as thoroughly investigated in a drug delivery perspective. Depending on body site, the combined follicle orifices cover up to 10% of the skin surface, while furrows can easily cover 20%, reaching depths exceeding 25 µm. Hence, porous particles of appropriate size and porosity could serve as carriers for drugs to be released in the follicles prior to local or systemic absorption. In this paper, we combine multiphoton microscopy, scanning electron microscopy, and Franz cell diffusion technology to investigate ex-vivo skin accumulation of mesoporous silica particles (average size of 400-600 nm, 2, and 7 µm, respectively), and the potential of which as vehicles for topical drug delivery of the broad-spectrum antibiotic metronidazole. We detected smaller particles (400-600 nm) in furrows at depths of about 25 µm, also after rinsing, while larger particles (7 µm) where located more superficially on the skin. This implies that appropriately sized porous particles may serve as valuable excipients in optimizing bioavailability of topical formulations. This work highlights the potential of skin furrows for topical drug delivery.

Place, publisher, year, edition, pages
Elsevier, 2021. Vol. 602, article id 120609
Keywords [en]
dermal drug delivery, multiphoton microscopy, nanoparticles, skin topography, targeted delivery
National Category
Pharmaceutical Sciences
Identifiers
URN: urn:nbn:se:mau:diva-42122DOI: 10.1016/j.ijpharm.2021.120609ISI: 000657606400004PubMedID: 33901597Scopus ID: 2-s2.0-85105266815OAI: oai:DiVA.org:mau-42122DiVA, id: diva2:1553061
Available from: 2021-05-07 Created: 2021-05-07 Last updated: 2024-02-05Bibliographically approved

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Valetti, SabrinaFalkman, PeterEngblom, Johan

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