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Dual roles of 3-aminopropyltriethoxysilane in preparing molecularly imprinted silica particles for specific recognition of target molecules
College of Chemistry, Nanchang University Nanchang Jiangxi 330031 China.
School of Chemistry and Chemical Engineering, Qufu Normal University Qufu Shandong 273165 China.
Department of Food Science and Engineering, School of Food Science and Pharmaceutical Engineering, Nanjing Normal University Nanjing 210023 China.
Malmö University, Faculty of Health and Society (HS), Department of Biomedical Science (BMV). Malmö University, Biofilms Research Center for Biointerfaces.
2020 (English)In: RSC Advances, E-ISSN 2046-2069, Vol. 10, no 34, p. 20368-20373Article in journal (Refereed) Published
Abstract [en]

3-Aminopropyltriethoxysilane (APTES) is a silane widely used to supply amino groups for further modifications on various materials, but it is less studied as a catalyst to catalyze sol-gel silica polymerization. Here, by using APTES as the catalyst instead of the conventional basic catalysts, a novel strategy was developed to prepare silica-based molecularly imprinted polymers (MIPs). Meanwhile, APTES was employed as the functional monomer to create imprinted nanocavities for specific recognition of target molecules. The as-synthesized MIP exhibited ultra-high recognition capability due to the elimination of the detrimental effect on the imprinting performance caused by the additional catalysts. The preparation process, specificity, pH effect, binding capacity and affinity of the MIP were studied in detail. The MIP microparticles could be packed into a solid phase extraction column for removing the target molecule in water efficiently, and the molecule could easily be enriched by 40 times. The interaction of the functional monomer and template was studied by the calculation method, giving a more clear understanding of the recognition behaviours of the imprinted polymers. The strategy could be extended not only to prepare highly specific MIPs for other small phosphoric molecules, but also for biomolecules e.g. phosphorylated peptides or proteins.

Place, publisher, year, edition, pages
Royal Society of Chemistry, 2020. Vol. 10, no 34, p. 20368-20373
National Category
Organic Chemistry
Identifiers
URN: urn:nbn:se:mau:diva-17870DOI: 10.1039/d0ra01684eISI: 000541906600063PubMedID: 35520410Scopus ID: 2-s2.0-85085615701OAI: oai:DiVA.org:mau-17870DiVA, id: diva2:1456407
Available from: 2020-08-04 Created: 2020-08-04 Last updated: 2024-06-17Bibliographically approved

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Abouhany, Rahma

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