Dehydration affects drug transport over nasal mucosaShow others and affiliations
2019 (English)In: Drug Delivery, ISSN 1071-7544, E-ISSN 1521-0464, Vol. 26, no 1, p. 831-840Article in journal (Refereed) Published
Abstract [en]
Formulations for nasal drug delivery often rely on water sorption to adhere to the mucosa, which also causes a higher water gradient over the tissue and subsequent dehydration. The primary aim of this study was therefore to evaluate mucosal response to dehydration and resolve the hypothesis that mucoadhesion achieved through water sorption could also be a constraint for drug absorption via the nasal route. The effect of altering water activity of the vehicle on Xylometazoline HCl and Cr-EDTA uptake was studied separately using flow through diffusion cells and excised porcine mucosa. We have shown that a modest increase in the water gradient over mucosa induces a substantial decrease in drug uptake for both Xylometazoline HCl and Cr-EDTA. A similar result was obtained when comparing two different vehicles on the market; Nasoferm (Nordic Drugs, Sweden) and BLOX4 (Bioglan, Sweden). Mucoadhesion based on water sorption can slow down drug uptake in the nasal cavity. However, a clinical study is required to determine whether prolonged duration of the vehicle or preventing dehydration of the mucosa is the most important factor for improving bioavailability.
Place, publisher, year, edition, pages
Taylor & Francis, 2019. Vol. 26, no 1, p. 831-840
Keywords [en]
Mucoadhesion, dehydration, drug transport, nasal drug delivery, water activity
National Category
Pharmaceutical Sciences
Identifiers
URN: urn:nbn:se:mau:diva-15215DOI: 10.1080/10717544.2019.1650848ISI: 000480247200001PubMedID: 31401887Scopus ID: 2-s2.0-85071047269Local ID: 29688OAI: oai:DiVA.org:mau-15215DiVA, id: diva2:1418736
2020-03-302020-03-302024-02-05Bibliographically approved
In thesis