Malmö University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Sphingoid Bases Inhibit Acid-Induced Demineralization of Hydroxyapatite
Show others and affiliations
2015 (English)In: Caries Research, ISSN 0008-6568, E-ISSN 1421-976X, Vol. 49, no 1, p. 9-17Article in journal (Refereed) Published
Abstract [en]

Calcium hydroxyapatite (HAp), the main constituent of dental enamel, is inherently susceptible to the etching and dissolving action of acids, resulting in tooth decay such as dental caries and dental erosion. Since the prevalence of erosive wear is gradually increasing, there is urgent need for agents that protect the enamel against erosive attacks. In the present study we studied in vitro the anti-erosive effects of a number of sphingolipids and sphingoid bases, which form the backbone of sphingolipids. Pretreatment of HAp discs with sphingosine, phytosphingosine (PHS), PHS phosphate and sphinganine significantly protected these against acid-induced demineralization by 80 ± 17%, 78 ± 17%, 78 ± 7% and 81 ± 8%, respectively (p < 0.001). On the other hand, sphingomyelin, acetyl PHS, octanoyl PHS and stearoyl PHS had no anti-erosive effects. Atomic force measurement revealed that HAp discs treated with PHS were almost completely and homogeneously covered by patches of PHS. This suggests that PHS and other sphingoid bases form layers on the surface of HAp, which act as diffusion barriers against H+ ions. In principle, these anti-erosive properties make PHS and related sphingosines promising and attractive candidates as ingredients in oral care products.

Place, publisher, year, edition, pages
S. Karger, 2015. Vol. 49, no 1, p. 9-17
Keywords [en]
Erosion, Hydroxyapatite, Lipids, Phytosphingosine, Protection
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:mau:diva-15163DOI: 10.1159/000362096ISI: 000346584800002PubMedID: 25300299Scopus ID: 2-s2.0-84923516963Local ID: 18610OAI: oai:DiVA.org:mau-15163DiVA, id: diva2:1418684
Available from: 2020-03-30 Created: 2020-03-30 Last updated: 2024-02-05Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Authority records

Sotres, JavierLindh, LiselottArnebrant, Thomas

Search in DiVA

By author/editor
Sotres, JavierLindh, LiselottArnebrant, Thomas
By organisation
Department of Biomedical Science (BMV)Faculty of Odontology (OD)
In the same journal
Caries Research
Natural Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 21 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf