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On-chip determination of dopamine exocytosis using mercaptopropionic acid modified microelectrodes
Department of Analytical Chemistry, Lund University, P. O. Box 124, SE-221 00 Lund, Sweden; Sophion Bioscience A/S, Baltorpvej 154, DK-2750, Ballerup, Denmark.
Department of Analytical Chemistry, Lund University, P. O. Box 124, SE-221 00 Lund, Sweden.
Department of Analytical Chemistry, Lund University, P. O. Box 124, SE-221 00 Lund, Sweden.
NanoDTU, MIC – Department of Micro and Nanotechnology, Technical University of Denmark, DK-2800 Kongens Lyngby, Denmark.
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2007 (Engelska)Ingår i: Electroanalysis, ISSN 1040-0397, E-ISSN 1521-4109, Vol. 19, nr 2-3, s. 263-271Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Gold and platinum, which often are used for thin film metallization, are not suitable for the measurement of dopamine (DA), since the oxidation product of DA forms a non-conducting polymer on the electrode surface. In this work several thiols were screened for their ability to prevent this polymerization. It was found that mercaptopropionic acid (MPA) decreased the rate of DA polymerization. MPA, possessing a weak acidic functionality, had the greatest effect on the DA electrochemistry by decreasing electrode passivation, as well as improving reversibility and sensitivity. Modifications of microchip electrodes with MPA did not only improve DA electrochemistry but also significantly increased the storage stability of the transducers. The microchips were ultimately used to detect K+ stimulated quantal release of DA from PC12 cells.

Ort, förlag, år, upplaga, sidor
John Wiley & Sons, 2007. Vol. 19, nr 2-3, s. 263-271
Nyckelord [en]
exocytosis, dopamine
Nationell ämneskategori
Analytisk kemi
Identifikatorer
URN: urn:nbn:se:mau:diva-14713DOI: 10.1002/elan.200603720ISI: 000244220700021Scopus ID: 2-s2.0-34547560083Lokalt ID: 4609OAI: oai:DiVA.org:mau-14713DiVA, id: diva2:1418234
Tillgänglig från: 2020-03-30 Skapad: 2020-03-30 Senast uppdaterad: 2024-05-06Bibliografiskt granskad

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Ruzgas, Tautgirdas

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Totalt: 22 träffar
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