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Targeted Photodynamic Therapy with a Folate/Sensitizer Assembly Produced from Mesoporous Silica
Nanologica AB, 151 36, Södertälje, Sweden.
Laboratory of Photochemistry, Department of Drug Sciences, University of Catania, 95125, Catania, Italy.
Malmö högskola, Faculty of Health and Society (HS), Department of Biomedical Science (BMV). Malmö högskola, Biofilms Research Center for Biointerfaces. Nanologica AB, 151 36, Södertälje, Sweden.ORCID iD: 0000-0002-2535-7108
Nanologica AB, 151 36, Södertälje, Sweden; Surface and Corrosion Science, KTH Royal Institute of Technology, 100 44, Stockholm, Sweden.
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2017 (English)In: Chemistry - A European Journal, ISSN 0947-6539, E-ISSN 1521-3765, Vol. 23, no 32, p. 7672-7676Article in journal (Refereed) Published
Abstract [en]

A mesoporous silica material prepared by using folic acid (FA) as a template enables the effective encapsulation of meso-tetrakis(4-carboxyphenyl)porphyrin (TCPP) in its interior. Combination of steady-state and time-resolved absorption and emission spectroscopy demonstrate that FA and TCPP are released from the silica material to the aqueous phase in the form of a non-covalent assembly. This assembly does not form by simple mixing of the two components in the absence of silica, suggesting the key role of the material in the assembling process. The FA/TCPP assembly exhibits dual color fluorescence in the visible region, good photosensitization capability of singlet oxygen, and enhanced photo-induced mortality in KB cancer cells overexpressing folate receptor, if compared with the free components.

Place, publisher, year, edition, pages
John Wiley & Sons, 2017. Vol. 23, no 32, p. 7672-7676
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Medical and Health Sciences
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URN: urn:nbn:se:mau:diva-5104DOI: 10.1002/chem.201701432ISI: 000402799200007PubMedID: 28444786Scopus ID: 2-s2.0-85018861535Local ID: 24198OAI: oai:DiVA.org:mau-5104DiVA, id: diva2:1401939
Available from: 2020-02-28 Created: 2020-02-28 Last updated: 2024-06-17Bibliographically approved

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Valetti, SabrinaConoci, Sabrina

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