This chapter describes autotransplantation of teeth, which is a viable treatment alternative for replacing traumatically lost or congenitally missing teeth by moving a tooth or a root to a more suitable position within the same individual. Usually, premolars and third molars are considered donor teeth. The chapter presents an overview of important principles for case selection, surgical technique, and tissue healing, which are prerequisites for a successful result. The key to successful autotransplantation has shown to be related to proper selection of donor teeth with adequate root development and applying the proper nontraumatic surgical techniques. Autotransplantation has its optimum success in young patients, that is, a period when implants are generally contraindicated. Given the consideration discussed in this chapter and careful case selection and planning, the possibility of tooth autotransplantation is an excellent treatment option, especially suitable in young individuals with missing teeth.