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Multivalent mesoporous silica nanoparticles photodelivering nitric oxide with carbon dots as fluorescent reporters
Laboratory of Photochemistry, Department of Drug Sciences, Viale Andrea Doria 6, 95125, Catania, Italy.
Malmö högskola, Fakulteten för hälsa och samhälle (HS), Institutionen för biomedicinsk vetenskap (BMV). Malmö högskola, Biofilms Research Center for Biointerfaces. Nanologica AB, Södertälje, SE-151 36, Sweden.ORCID-id: 0000-0002-2535-7108
Laboratory of Photochemistry, Department of Drug Sciences, Viale Andrea Doria 6, Catania, 95125, Italy.
Laboratory of Photochemistry, Department of Drug Sciences, Viale Andrea Doria 6, Catania, 95125, Italy.
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2017 (engelsk)Inngår i: Nanoscale, ISSN 2040-3364, E-ISSN 2040-3372, Vol. 9Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Amino-terminated mesoporous silica nanoparticles embedding carbon dots (MSCD) formed by calcination were functionalized with a nitric oxide (NO) photodonor (1) to give a robust MSCD-1 conjugate. The intense fluorescence of MSCDs was strongly quenched in MSCD-1 by effective energy transfer. Visible light excitation of MSCD-1 liberates NO, suppresses the energy transfer mechanism and leads to concomitant fluorescence restoration of the MSCD scaffold, which acts as an optical reporter for the released NO. The MSCD-1 hybrid is also able to encapsulate the highly hydrophobic photosensitizer temoporfin, preserving the fluorescence reporting function.

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Royal Society of Chemistry, 2017. Vol. 9
HSV kategori
Identifikatorer
URN: urn:nbn:se:mau:diva-3970DOI: 10.1039/C7NR04832GISI: 000411613400003PubMedID: 28813066Scopus ID: 2-s2.0-85029830613Lokal ID: 24194OAI: oai:DiVA.org:mau-3970DiVA, id: diva2:1400794
Tilgjengelig fra: 2020-02-28 Laget: 2020-02-28 Sist oppdatert: 2024-06-17bibliografisk kontrollert

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