The aim of the present investigation is to analyze the reasons for peri-implantitis in animal models and couple these findings to results from retrospective and prospective clinical studies of oral implants. The inflammatory and immune response to titanium and polyethylene, a commonly used clinical material,  will be compared with methods such as quantitative real time polymerase chain reaction (qRT-PCR) for molecular and cellular mediators related gene expression and by histological examinations. In the next step similar implants will be coated with nano-structure impregnated with anti-inflammatory or/and immune suppressive components or with pro-inflammatory agents. Results will be correlated to those from the previous animal study and will hypothetically present a clear view on spatial and temporal roles of immunology and inflammation for the control of osseointegration/FBE.