Open this publication in new window or tab >>2023 (English)In: PLOS ONE, E-ISSN 1932-6203, Vol. 18, no 5, p. e0285583-e0285583Article in journal (Refereed) Published
Abstract [en]
Background/Aim: Opioid overdose deaths have increased in Sweden and other developed countries in recentdecades, despite increased treatment efforts and harm-reduction interventions. Furtherknowledge in this field is needed if this trend is to be reversed. Previous research suggeststhat mental health and patterns of prescription of opioids and other prescription drugs areassociated with increased opioid-related mortality. The present study therefore aimed toinvestigate what drugs were prescribed during the last six months of life to individuals with ahistory of illicit substance use who died with opioids present in their blood, the relationshipbetween drugs prescribed and drugs found in blood at time of death, and if prescription ofspecific drugs was temporally associated with death.
Methods: This was a retrospective, register-based observational study that utilized data from theNational Board of Forensic Medicine, the Prescribed Drug Registry, regional health careservices, and municipal social services. We used conditional logistic regression to findtemporal associations between the prescription and dispensing of drugs and time ofdeath.
Results: Prescription and dispensing of alprazolam and diazepam were temporally associated withdeath. The most frequently dispensed drugs were zopiclone, pregabalin, methylphenidate,diazepam and oxycodone. Methadone, alprazolam, and buprenorphine were the drugsmost often found in the blood. Opioids and tranquilizers in combination were found in a vastmajority of deaths, and prescription data suggested that the use of these drugs was illicit in amajority of cases.
Conclusion: Prescription of certain drugs, especially alprazolam and diazepam, should be made withgreat caution to patients with a history of illicit substance use or concurrent use of opioids.
Place, publisher, year, edition, pages
Public Library of Science (PLoS), 2023
National Category
Drug Abuse and Addiction
Identifiers
urn:nbn:se:mau:diva-59927 (URN)10.1371/journal.pone.0285583 (DOI)001024638000001 ()37256903 (PubMedID)2-s2.0-85160737010 (Scopus ID)
Funder
Region Skåne
2023-06-022023-06-022025-02-11Bibliographically approved