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Psotta, C., Cirovic, S., Gudmundsson, P., Falk, M., Mandal, T., Reichhart, T., . . . Shleev, S. (2023). Continuous ex vivo glucose sensing in human physiological fluids using an enzymatic sensor in a vein replica. Bioelectrochemistry, 152, Article ID 108441.
Öppna denna publikation i ny flik eller fönster >>Continuous ex vivo glucose sensing in human physiological fluids using an enzymatic sensor in a vein replica
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2023 (Engelska)Ingår i: Bioelectrochemistry, ISSN 1567-5394, E-ISSN 1878-562X, Vol. 152, artikel-id 108441Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Managing blood glucose can affect important clinical outcomes during the intraoperative phase of surgery. However, currently available instruments for glucose monitoring during surgery are few and not optimized for the specific application. Here we report an attempt to exploit an enzymatic sensor in a vein replica that could continuously monitor glucose level in an authentic human bloodstream. First, detailed investigations of the superficial venous systems of volunteers were carried out using ocular and palpating examinations, as well as advanced ultrasound measurements. Second, a tubular glucose-sensitive biosensor mimicking a venous system was designed and tested. Almost ideal linear dependence of current output on glucose concentration in phosphate buffer saline was obtained in the range 2.2-22.0 mM, whereas the dependence in human plasma was less linear. Finally, the developed biosensor was investigated in whole blood under homeostatic conditions. A specific correlation was found between the current output and glucose concentration at the initial stage of the biodevice operation. However, with time, blood coagulation during measurements negatively affected the performance of the biodevice. When the experimental results were remodeled to predict the response without the influence of blood coagulation, the sensor output closely followed the blood glucose level.

Ort, förlag, år, upplaga, sidor
Elsevier, 2023
Nyckelord
Continuous glucose sensing, Enzymatic sensor, Vein replica, Human physiological fluids, Surgery
Nationell ämneskategori
Endokrinologi och diabetes
Identifikatorer
urn:nbn:se:mau:diva-61052 (URN)10.1016/j.bioelechem.2023.108441 (DOI)000984583000001 ()37087795 (PubMedID)2-s2.0-85153044643 (Scopus ID)
Tillgänglig från: 2023-06-20 Skapad: 2023-06-20 Senast uppdaterad: 2024-02-26Bibliografiskt granskad
Dieden, A., Gudmundsson, P., Korduner, J., Molvin, J., Zaghi, A., Nezami, Z., . . . Magnusson, M. (2023). Galectin-4 is associated with diabetes and obesity in a heart failure population. Scientific Reports, 13(1), Article ID 20285.
Öppna denna publikation i ny flik eller fönster >>Galectin-4 is associated with diabetes and obesity in a heart failure population
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2023 (Engelska)Ingår i: Scientific Reports, E-ISSN 2045-2322, Vol. 13, nr 1, artikel-id 20285Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

An association between high Galectin-4 (Gal-4) and prevalence of diabetes in subjects with heart failure (HF) has previously been reported. The purpose of this study was to confirm these findings, as well as to further investigate this association, in a Swedish HF population. In addition, a second aim was to explore Gal-4's association with obesity and biomarkers of metabolism and heart failure. Gal-4 was measured using a proximity extension array technique in 324 hospitalized HF patients within the Swedish HeArt and bRain failure investigation trial cohort. Obesity was defined as BMI ≥ 30. Multivariable logistic regression models were used to explore associations between Gal-4 and diabetes/obesity, and linear regression models were used to explore the associations between Gal-4 and biomarkers. A total of 309 participants (29.1% female; mean age 74.8 years) provided complete data for the analysis of associations between Gal-4 and diabetes. Additionally, for the analysis of heart failure phenotype, complete data was available for 230 subjects. Gal-4 was positively associated with prevalent diabetes (OR 2.60; CI 95% 1.56-4.32). In multivariable models, Gal-4 levels were significantly associated with obesity, but only for subjects with diabetes (OR 2.48; 1.09-5.62). Additionally, Gal-4 demonstrated a significant association with the incretin Glucose-dependent insulinotropic polypeptide (GIP), as well as with biomarkers of HF. In the stratified analyses, the association between Gal-4 and diabetes was prominent in patients with reduced ejection fraction (n = 160, OR 3.26; 95%CI 1.88-5.66), while it was not observed in those without (n = 70, 1.96 (0.75-5.10)). In this cross-sectional, observational study, higher Gal-4 levels in HF patients were associated with higher GIP levels. Further, increased levels of Gal-4 were associated with increased likelihood of diabetes, and obesity. This association was particularly pronounced in individuals with HF characterized by reduced ejection fraction. Additionally, Gal-4 levels were significantly elevated in heart failure patients with diabetes and obesity.

Ort, förlag, år, upplaga, sidor
Springer Nature, 2023
Nationell ämneskategori
Kardiologi
Identifikatorer
urn:nbn:se:mau:diva-64109 (URN)10.1038/s41598-023-47426-9 (DOI)37985679 (PubMedID)2-s2.0-85177431823 (Scopus ID)
Tillgänglig från: 2023-12-06 Skapad: 2023-12-06 Senast uppdaterad: 2023-12-06Bibliografiskt granskad
Dieden, A., Holm, H., Molvin, J., Korduner, J., Nezami, Z., Zaghi, A., . . . Magnusson, M. (2023). Galectin-4 is associated with diabetes in a heart failure population. Paper presented at Heart Failure 2023 and the World Congress on Acute Heart Failure, 20 ‐ 23 May 2023, Prague, Czechia. European Journal of Heart Failure, 25(S2), 317-318
Öppna denna publikation i ny flik eller fönster >>Galectin-4 is associated with diabetes in a heart failure population
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2023 (Engelska)Ingår i: European Journal of Heart Failure, ISSN 1388-9842, E-ISSN 1879-0844, Vol. 25, nr S2, s. 317-318Artikel i tidskrift, Meeting abstract (Övrigt vetenskapligt) Published
Ort, förlag, år, upplaga, sidor
John Wiley & Sons, 2023
Nationell ämneskategori
Kardiologi
Identifikatorer
urn:nbn:se:mau:diva-64073 (URN)001043122801214 ()
Konferens
Heart Failure 2023 and the World Congress on Acute Heart Failure, 20 ‐ 23 May 2023, Prague, Czechia
Tillgänglig från: 2023-12-05 Skapad: 2023-12-05 Senast uppdaterad: 2023-12-05Bibliografiskt granskad
Slates, S., Cook-Sather, A., Aghakhani, S., Al-Humuzi, A., Alonso, D., Borgström, K., . . . Zou, W. (2023). How can students-as-partners work address challenges to student, faculty, and staff mental health and well-being?. International Journal for Students as Partners, 7(2), 221-240
Öppna denna publikation i ny flik eller fönster >>How can students-as-partners work address challenges to student, faculty, and staff mental health and well-being?
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2023 (Engelska)Ingår i: International Journal for Students as Partners, E-ISSN 2560-7367, Vol. 7, nr 2, s. 221-240Artikel i tidskrift (Övrig (populärvetenskap, debatt, mm)) Published
Ort, förlag, år, upplaga, sidor
McMaster University Press, 2023
Nationell ämneskategori
Utbildningsvetenskap
Identifikatorer
urn:nbn:se:mau:diva-63173 (URN)10.15173/ijsap.v7i2.5597 (DOI)
Projekt
Vertically Integrated Project
Tillgänglig från: 2023-10-17 Skapad: 2023-10-17 Senast uppdaterad: 2023-10-19Bibliografiskt granskad
Cirovic, S., Malmgren, A., Kurdie, R., Bilal, D., Dencker, M. & Gudmundsson, P. (2023). Vortex formation time in female athletes. The International Journal of Cardiovascular Imaging
Öppna denna publikation i ny flik eller fönster >>Vortex formation time in female athletes
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2023 (Engelska)Ingår i: The International Journal of Cardiovascular Imaging, ISSN 1569-5794, E-ISSN 1875-8312Artikel i tidskrift (Refereegranskat) Epub ahead of print
Abstract [en]

Regular, vigorous physical activity can have a significant impact on cardiac function, leading to cardiac morphological alterations that may be challenging to distinguish from pathological changes. Therefore, new screening methods are needed to accurately differentiate between adaptive changes and pathological alterations in athletes. Vortex formation time (VFT) is an emerging method that shows potential in this regard, as it involves the formation of a rotating vortex ring in the left ventricle during the early filling phase of diastole. In this study, we investigated the difference in VFT between two groups of women: professional handball players and healthy middle-aged female athletes, along with their corresponding control groups. By using echocardiography-Doppler analysis of the heart, VFT was calculated based on the left ventricular ejection fraction, the ratio between the end-diastolic volume and the diameter of the mitral annulus, and the ratio of the atrial contraction volume to the total inflow via the mitral valve. The study reveals a significant increase in VFT in both professional handball players and middle-aged female athletes compared to their respective control groups. Moreover, statistically significant differences between handball players and middle-aged female athletes were observed, indicating that the level of physical activity may affect the VFT. These results suggest that VFT could be a promising screening tool for identifying cardiac adaptations due to long-term vigorous training, potentially enabling more accurate diagnoses of cardiac morphological alterations in athletes. Representation of the graphical abstract of the conducted research.

Ort, förlag, år, upplaga, sidor
Springer Nature, 2023
Nyckelord
Doppler analysis, Female participants, New screening methods, Vortex formation time
Nationell ämneskategori
Kardiologi Idrottsvetenskap
Identifikatorer
urn:nbn:se:mau:diva-64115 (URN)10.1007/s10554-023-02995-8 (DOI)001118537100001 ()38008878 (PubMedID)2-s2.0-85178284310 (Scopus ID)
Tillgänglig från: 2023-12-07 Skapad: 2023-12-07 Senast uppdaterad: 2024-02-26Bibliografiskt granskad
Dieden, A., Helm, H., Melander, O., Pareek, M., Molvin, J., Rastam, L., . . . Magnusson, M. (2022). Biomarkers associated with prevalent hypertension and higher blood pressure in a population-based cohort: a proteomic approach. European Heart Journal, 43(Suppl 2), 2189-2189
Öppna denna publikation i ny flik eller fönster >>Biomarkers associated with prevalent hypertension and higher blood pressure in a population-based cohort: a proteomic approach
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2022 (Engelska)Ingår i: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 43, nr Suppl 2, s. 2189-2189Artikel i tidskrift, Meeting abstract (Övrigt vetenskapligt) Published
Abstract [en]

BackgroundGlobally, hypertension represents an enormous health issue as it is a major, yet modifiable risk factor for developing cardiovascular disease. Recently, chitinase-3-like protein 1 (CHI3L1) was shown to be positively associated with the incidence of hypertension among prehypertensive subjects, and variants of CHI3L1 gene were associated with both CHI3L1-levels and hypertension.PurposeTo explore associations between prevalent hypertension and blood pressure, and 92 proteins with involvement in inflammation and cardiovascular disease.MethodsPlasma samples from 1713 individuals from a Swedish population-based cohort (mean age 67.3±6.0 years; 28.9% women) were analysed with a proximity extension assay panel, consisting of 92 proteins. Prior to all analyses, subjects with prevalent cardiovascular disease, defined as having a history of prevalent coronary or stroke event, were excluded (n=189). Univariate logistic regression models were carried out exploring associations between each of the 92 proteins and prevalent hypertension, defined as systolic blood pressure ≥140 mmHg and/or a diastolic blood pressure ≥90 mmHg, or use of antihypertensive treatment (n=1168, 76.4%). Bonferroni-corrected significant associations between proteins and hypertension were further analysed using stepwise selection of covariates, namely age, body mass index, diabetes status, and cystatin C, in logistic regression models. Proteins with significant adjusted associations with prevalent hypertension were further analysed for associations with systolic and diastolic blood pressure individually in stepwise linear regression models. Complete data on all variables were available in 1527 subjects.ResultsSixteen proteins were significantly associated with prevalent hypertension in univariate analyses. After adjustment, three proteins remained significantly associated with prevalent hypertension (i.e., CHI3L1, low-density lipoprotein receptor (LDL receptor) and tissue plasminogen activator (tPA); Table 1). In analyses of associations with systolic blood pressure, CHI3L1 and LDL receptor showed significant associations. In analyses of associations with diastolic blood pressure, CHI3L1, LDL receptor and tPA showed significant associations (Table 1).ConclusionsHigher CHI3L1, tPA and LDL receptor levels were positively associated with prevalent hypertension after multivariable adjustment, among 1527 elderly subjects without established cardiovascular disease. Furthermore, higher CHI3L and LDL receptor levels were positively associated with mean systolic, as well as mean diastolic blood pressure in multivariable analyses.Funding AcknowledgementType of funding sources: Foundation. Main funding source(s): The Swedish Medical Research Council and The Swedish Heart and Lung Foundation

Ort, förlag, år, upplaga, sidor
Oxford University Press, 2022
Nationell ämneskategori
Kardiologi
Identifikatorer
urn:nbn:se:mau:diva-58686 (URN)10.1093/eurheartj/ehac544.2189 (DOI)000894947901413 ()
Tillgänglig från: 2023-03-20 Skapad: 2023-03-20 Senast uppdaterad: 2023-03-20Bibliografiskt granskad
Leijon, M., Gudmundsson, P., Staaf, P. & Christersson, C. (2022). Challenge based learning in higher education: A systematic literature review. Innovations in Education & Teaching International, 59(5), 609-618
Öppna denna publikation i ny flik eller fönster >>Challenge based learning in higher education: A systematic literature review
2022 (Engelska)Ingår i: Innovations in Education & Teaching International, ISSN 1470-3297, E-ISSN 1470-3300, Vol. 59, nr 5, s. 609-618Artikel, forskningsöversikt (Refereegranskat) Published
Abstract [en]

This review maps patterns in research on Challenge Based Learning (CBL) in higher education (HE) between 2009 and 2020. How is CBL defined in HE settings? How is CBL in HE grounded scientifically in the research? The results show a shift of CBL from being a concept coined by a multinational technology company targeting learning in schools, to being embraced by HE, first and foremost as a method for transformation of adult learning. A critical scientifically grounded approach towards learning is however absent or marginally present in the papers reviewed.

Ort, förlag, år, upplaga, sidor
Routledge, 2022
Nyckelord
Challenge-based learning, higher education, theories, adult learning
Nationell ämneskategori
Pedagogik
Identifikatorer
urn:nbn:se:mau:diva-41527 (URN)10.1080/14703297.2021.1892503 (DOI)000630668500001 ()2-s2.0-85102935107 (Scopus ID)
Tillgänglig från: 2021-04-01 Skapad: 2021-04-01 Senast uppdaterad: 2024-02-05Bibliografiskt granskad
Stollenwerk, M. M., Gustafsson, A., Edgren, G., Gudmundsson, P., Lindqvist, M. & Eriksson, T. (2022). Core competencies for a biomedical laboratory scientist - a Delphi study. BMC Medical Education, 22(1), Article ID 476.
Öppna denna publikation i ny flik eller fönster >>Core competencies for a biomedical laboratory scientist - a Delphi study
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2022 (Engelska)Ingår i: BMC Medical Education, E-ISSN 1472-6920, Vol. 22, nr 1, artikel-id 476Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background After completing university education, biomedical laboratory scientists work in clinical laboratories, in biomedical research laboratories, in biotech, and in pharmaceutical companies. Laboratory diagnostics have undergone rapid development over the recent years, with the pace showing no signs of abatement. This rapid development challenges the competence of the staff and will most certainly influence the education of future staff. This study aimed to examine what was considered the necessary competencies needed to pursue a career as a biomedical laboratory scientist. Methods A modified Delphi technique was used, with the panel of experts expressing their views in a series of three questionnaire. Consensus was defined as the point which 75 % or more of the panel participants agreed that a particular competency was necessary. Results The study highlights the perceived importance of mostly generic competencies that relate to quality, quality assurance, and accuracy, as well as different aspects of safety, respect, trustworthiness (towards patients/clients and colleagues), and communication skills. The results also stress the significance of self-awareness and professionality. Conclusions We identified important competencies for biomedical laboratory scientists. Together with complementary information from other sources, i.e., guidelines, laws, and scientific publications, the competencies identified can be used as learning outcomes in a competency-based education to provide students with all the competencies needed to work as professional biomedical laboratory scientists.

Ort, förlag, år, upplaga, sidor
BMC, 2022
Nyckelord
Core curriculum, Core competencies, Delphi, Biomedical laboratory scientists, Student, Expert group, Biomedical laboratory scientist degree
Nationell ämneskategori
Biomedicinsk laboratorievetenskap/teknologi Lärande
Identifikatorer
urn:nbn:se:mau:diva-54091 (URN)10.1186/s12909-022-03509-1 (DOI)000813777600002 ()35725406 (PubMedID)2-s2.0-85132263019 (Scopus ID)
Tillgänglig från: 2022-08-02 Skapad: 2022-08-02 Senast uppdaterad: 2024-02-05Bibliografiskt granskad
Carlson, E., Stigmar, M., Engberg, M., Falk, M., Stollenwerk, M. M., Gudmundsson, P. & Enskär, K. (2022). Students´ Experiences of Participation in a Research Team: Evaluation of a Research-based Teaching Activity in HigherEducation. International Journal for the Scholarship of Teaching & Learning, 16(3)
Öppna denna publikation i ny flik eller fönster >>Students´ Experiences of Participation in a Research Team: Evaluation of a Research-based Teaching Activity in HigherEducation
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2022 (Engelska)Ingår i: International Journal for the Scholarship of Teaching & Learning, E-ISSN 1931-4744, Vol. 16, nr 3Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

AbstractIn Sweden as well as internationally the teaching and research nexus has been described as the defining charac-teristics of higher education promoting generic skills such as information analysis and critical reflection. Vertically Integrated Projects has been proposed as one educational strategy where research and teaching are linked by in-viting students to take active part in actual research projects. The strategy is well aligned to Scholarship of teaching and learning enabling the transition from a teacher-centred accepted knowledge to a student-centred perspective where students are invited as producers of knowledge. The aim of the current study was to explore students’ experiences of participation in a research-based learning activity with academia and industrial partners, designed as a qualitative explorative study using focus group interviews. Findings describe not only factors students find motivating for learning, but also their experience of being part of professional life with its benefits and challenges.

Ort, förlag, år, upplaga, sidor
Faculty Center at Georgia Southern University., 2022
Nyckelord
Focus group, Interdisciplinary, Research-based learning, Students, Vertically Integrated Project
Nationell ämneskategori
Utbildningsvetenskap
Identifikatorer
urn:nbn:se:mau:diva-56407 (URN)
Tillgänglig från: 2022-12-01 Skapad: 2022-12-01 Senast uppdaterad: 2023-10-05Bibliografiskt granskad
Axelsson, M., Kottorp, A., Carlson, E., Gudmundsson, P., Kumlien, C. & Jakobsson, J. (2022). Translation and validation of the Swedish version of the IPECC-SET 9 item version. Journal of Interprofessional Care, 36(6), 900-907
Öppna denna publikation i ny flik eller fönster >>Translation and validation of the Swedish version of the IPECC-SET 9 item version
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2022 (Engelska)Ingår i: Journal of Interprofessional Care, ISSN 1356-1820, E-ISSN 1469-9567, Vol. 36, nr 6, s. 900-907Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Interprofessional Education (IPE) is essential to prepare future health-care professionals for collaborative practice, but IPE requires evaluation. One psychometrically sound instrument is the Interprofessional Education Collaborative Competence Self-Efficacy Tool consisting of nine items (IPECC-SET 9). This tool does not, to date, exist in a Swedish version. Therefore, the aim of this study was to translate and validate the Swedish version of the IPECC-SET 9. The English version was translated into Swedish and tested among 159 students in the 3-year Bachelor Programs in Nursing and in Biomedical Laboratory Science. The psychometric analysis was guided by a Rasch model, which showed that the items functioned well together, confirming unidimensionality, and that the person misfit was also lower than the set criterion. The separation index was 2.98, and the Rasch-equivalent Cronbach-alpha measure was estimated to .92, supporting internal consistency. No systematic differences on item level in IPECC-SET 9 further supported fairness in testing. The Swedish IPECC-SET 9 demonstrates sound psychometric properties and has the potential to be used as a measure of self-efficacy for competence in interprofessional collaborative practice among health profession students. However, the IPECC-SET 9 is recommended to be further tested in larger samples representing the entirety of health-care teams.

Ort, förlag, år, upplaga, sidor
Taylor & Francis, 2022
Nyckelord
Collaborative practice, interprofessional competence, interprofessional education, Rasch model, self-efficacy
Nationell ämneskategori
Omvårdnad
Identifikatorer
urn:nbn:se:mau:diva-50456 (URN)10.1080/13561820.2022.2034762 (DOI)000757295400001 ()35175872 (PubMedID)2-s2.0-85125311910 (Scopus ID)
Tillgänglig från: 2022-03-08 Skapad: 2022-03-08 Senast uppdaterad: 2024-02-05Bibliografiskt granskad
Projekt
Icke-invasiva biomedicinska multiparameterenheter: synliggörande av dolda tränings- och hälsoindikatorer; Malmö universitetStudenters beredskap och kompetens för interprofessionellt lärande och personlighetens betydelse samt patienters och närståendes erfarenheter av att delta i interprofessionellt lärande; Malmö universitet
Organisationer
Identifikatorer
ORCID-id: ORCID iD iconorcid.org/0000-0002-2863-1141

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