A mobile stroke unit (MSU) is a special type of ambulance, where stroke patients can be diagnosed and provided intravenous treatment, hence allowing to cut down the time to treatment for stroke patients. We present a discrete event simulation (DES) model to study the potential benefits of using MSUs in the southern health care region of Sweden (SHR). We included the activities and actions used in the SHR for stroke patient transportation as events in the DES model, and we generated a synthetic set of stroke patients as input for the simulation model. In a scenario study, we compared two scenarios, including three MSUs each, with the current situation, having only regular ambulances. We also performed a sensitivity analysis to further evaluate the presented DES model. For both MSU scenarios, our simulation results indicate that the average time to treatment is expected to decrease for the whole region and for each municipality of SHR. For example, the average time to treatment in the SHR is reduced from 1.31h in the baseline scenario to 1.20h and 1.23h for the two MSU scenarios. In addition, the share of stroke patients who are expected to receive treatment within one hour is increased by a factor of about 3 for both MSU scenarios.

With the Internet of Things paradigm, the data generated by the rapidly increasing number of connected devices lead to new possibilities, such as using machine learning for activity recognition in smart environments. However, it also introduces several challenges. The sensors of different devices might be mobile and of different types, i.e. there is a need to handle streaming data from a dynamic and heterogeneous set of sensors. In machine learning, the performance is often linked to the availability and quality of annotated data. Annotating data is in general costly, but it can be even more challenging if there is not any, or a very small amount of, annotated data to train the model on at the start of learning. To handle these issues, we implement interactive and adaptive systems. By including human-in-the-loop, which we refer to as interactive machine learning, the input from users can be utilized to build the model. The type of input used in interactive machine learning is typically annotations of the data, i.e. correctly labelled data points. Generally, it is assumed that the user always provides correct labels in accordance with the chosen interactive learning strategy. In many real-world applications these assumptions are not realistic however, as users might provide incorrect labels or not provide labels at all in line with the chosen strategy.

In this thesis we explore which interactive learning strategy types are possible in the given scenario and how they affect performance, as well as the effect of machine learning algorithms on the performance. We also study how a user who is not always reliable, i.e. who does not always provide a correct label when expected to, can affect performance. We propose a taxonomy of interactive online machine learning strategies and test how the different strategies affect performance through experiments on multiple datasets. Simulated experiments are compared to experiments with human participants, to verify the results. The findings show that the overall best performing interactive learning strategy is one where the user provides labels when current estimations are incorrect, but that the best performing machine learning algorithm depends on the problem scenario. The experiments also show that a decreased reliability of the user leads to decreased performance, especially when there is a limited amount of labelled data. The robustness of the machine learning algorithms differs, where e.g. Naïve Bayes classifier is better at handling a lower reliability of the user. We also present a systematic literature review on machine teaching, a subfield of interactive machine learning where the human is proactive in the interaction. The study shows that the area of machine teaching is rapidly evolving with an increased number of publications in recent years. However, as it is still maturing, there exists several open challenges that would benefit from further exploration, e.g. how human factors can affect performance.

The use of artificial intelligence and machine learning techniques across all disciplines has exploded in the past few years, with the ever-growing size of data and the changing needs of higher education, such as digital education. Similarly, online educational information systems have a huge amount of data related to students in digital education. This educational data can be used with artificial intelligence and machine learning techniques to improve digital education. This study makes two main contributions. First, the study follows a repeatable and objective process of exploring the literature. Second, the study outlines and explains the literature's themes related to the use of AI-based algorithms in digital education. The study findings present six themes related to the use of machines in digital education. The synthesized evidence in this study suggests that machine learning and deep learning algorithms are used in several themes of digital learning. These themes include using intelligent tutors, dropout predictions, performance predictions, adaptive and predictive learning and learning styles, analytics and group-based learning, and automation. artificial neural network and support vector machine algorithms appear to be utilized among all the identified themes, followed by random forest, decision tree, naive Bayes, and logistic regression algorithms.

Focal application of transcranial static magnetic field stimulation (tSMS) over the human motor cortex induces local changes in cortical excitability. Whether tSMS can also induce distant network effects, and how these local and distant effects may vary over time, is currently unknown. In this study, we applied 10 min tSMS over the left motor cortex of healthy subjects using a real/sham parallel design. To measure tSMS effects at the sensori-motor network level, we used resting-state fMRI. Real tSMS, but not sham, reduced functional connectivity within the stimulated sensori-motor network. This effect of tSMS showed time-dependency, returning to sham levels after the first 5 min of fMRI scanning. With 10 min real tSMS over the motor cortex we did not observe effects in other functional networks examined (default mode and visual system networks). In conclusion, 10 min of tSMS over a location within the sensori-motor network reduces functional connectivity within the same functional network.

The main emphasis of this work is placed on the problem of collaborative coverage path planning for unmanned surface mapping vehicles (USMVs). As a result, the collaborative coverage improved BA* algorithm (CCIBA*) is proposed. In the algorithm, coverage path planning for a single vehicle is achieved by task decomposition and level map updating. Then a multiple USMV collaborative behavior strategy is designed, which is composed of area division, recall and transfer, area exchange and recognizing obstacles. Moverover, multiple USMV collaborative coverage path planning can be achieved. Consequently, a high-efficiency and high-quality coverage path for USMVs can be implemented. Water area simulation results indicate that our CCIBA* brings about a substantial increase in the performances of path length, number of turning, number of units and coverage rate.

In rural areas with low demand, demand responsive transport (DRT) can provide an alternative to the regular public transport bus lines, which are expensive to operate in such conditions. With simulation, we explore the potential effects of introducing a DRT service that replaces existing bus lines in Lolland municipality in Denmark, assuming that the existing demand remains unchanged. We set up the DRT service in such a way that its service quality (in terms of waiting time and in-vehicle time) is comparable to the replaced buses. The results show that a DRT service can be more cost efficient than regular buses and can produce significantly less CO2 emissions when the demand level is low. Additionally, we analyse the demand density at which regular buses become more cost efficient and explore how the target service quality of a DRT service can affect operational characteristics. Overall, we argue that DRT could be a more sustainable mode of public transport in low demand areas.

A fuzzy Petri net (FPN) is a powerful tool to model and analyze knowledge-based systems containing vague information. This paper systematically reviews recent developments of the FPN model from the following three perspectives: knowledge representation using FPN, reasoning mechanisms using an FPN framework, and the latest industrial applications using FPN. In addition, some specific modeling and reasoning approaches to FPN to solve the 'state-explosion problem' are illustrated. Furthermore, detailed analysis of the discussed aspects are shown to reveal some interesting findings, as well as their developmental history. Finally, we present conclusions and suggestions for future research directions.

Internet of Things (IoT) can work as a useful tool for clinical research. We developed a software platform that allows researchers to publish clinical studies and volunteers to participate into them using an app and connected IoT devices. The platform includes a REST API, a web interface for researchers and an app that collects data during tasks volunteers are invited to contribute. Nine tasks have been developed: Forms, Positioning, Finger tapping, Pulse-oximetry, Peak Flow measurement, Activity tracking, Data query, Queen’s College step test and Six-minute walk test. These leverage sensors embedded in the phone, connected Bluetooth devices and additional APIs like HealthKit and Google Fit. Currently, the platform is used in two clinical studies by 25 patients: an asthma management study in the United Kingdom, and a neuropathic pain management study in Spain.