Malmö University Publications
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  • 1.
    Svensson, Birgitta
    et al.
    Department of Cardiology, Pediatric Heart Centre, Skåne University Hospital and Lund University, Lund, Sweden.
    Idvall, Ewa
    Malmö University, Faculty of Health and Society (HS), Department of Care Science (VV).
    Nilsson, Fredrik
    Clinical Studies Sweden-Forum South, Skåne University Hospital, Lund, Sweden.
    Liuba, Petru
    Department of Cardiology, Pediatric Heart Centre, Skåne University Hospital and Lund University, Lund, Sweden.
    Health-Related Quality of Life in Children With Earlier Surgical Repair for Right Ventricular Outflow Tract Anomalies and the Agreement Between Children and Their Parents.2020In: Frontiers in Cardiovascular Medicine, E-ISSN 2297-055X, Vol. 7, article id 66Article in journal (Refereed)
    Abstract [en]

    HRQoL problems as perceived by children with RVOT anomalies are best identified with the PedsQL Cardiac Module and relate mostly to cognitive and physical functioning. The agreement findings suggest the need to take into account both child- and parent reports in the assessment of HRQoL.

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  • 2.
    Zaghi, Amir
    et al.
    Lund Univ, Dept Clin Sci, Malmo, Sweden..
    Holm, Hannes
    Lund Univ, Dept Clin Sci, Malmo, Sweden.;Lund Univ, Skane Univ Hosp, Dept Cardiol, Malmo, Sweden..
    Korduner, Johan
    Lund Univ, Dept Clin Sci, Malmo, Sweden.;Lund Univ, Skane Univ Hosp, Dept Internal Med, Malmo, Sweden..
    Dieden, Anna
    Malmö University, Faculty of Health and Society (HS), Department of Biomedical Science (BMV). Malmö University, Biofilms Research Center for Biointerfaces. Lund Univ, Dept Clin Sci, Malmo, Sweden..
    Molvin, John
    Lund Univ, Dept Clin Sci, Malmo, Sweden.;Lund Univ, Skane Univ Hosp, Dept Cardiol, Malmo, Sweden..
    Bachus, Erasmus
    Lund Univ, Dept Clin Sci, Malmo, Sweden..
    Jujic, Amra
    Lund Univ, Dept Clin Sci, Malmo, Sweden.;Lund Univ, Skane Univ Hosp, Dept Cardiol, Malmo, Sweden.;Lund Univ, Lund Univ Diabet Ctr, Malmo, Sweden..
    Magnusson, Martin
    Lund Univ, Dept Clin Sci, Malmo, Sweden.;Lund Univ, Skane Univ Hosp, Dept Cardiol, Malmo, Sweden.;Lund Univ, Wallenberg Ctr Mol Med, Lund, Sweden.;Northwest Univ, Hypertens Africa Res Team, Potchefstroom, South Africa..
    Physical Inactivity Is Associated With Post-discharge Mortality and Re-hospitalization Risk Among Swedish Heart Failure Patients-The HARVEST-Malmö Study2022In: Frontiers in Cardiovascular Medicine, E-ISSN 2297-055X, Vol. 9, article id 843029Article in journal (Refereed)
    Abstract [en]

    BackgroundSeveral studies have examined the role of physical activity as a predictor of heart failure (HF) mortality and morbidity. Here, we aimed to evaluate the role of self-reported physical activity as an independent risk factor of post-discharge mortality and re-hospitalization in patients hospitalized for HF, as well as study the association between physical activity and 92 plasma proteins associated with cardiovascular disease (CVD). MethodsFour-hundred-and-thirty-four patients hospitalized for HF (mean age 75 years; 32% women) were screened for physical activity derived from questionnaires in the Swedish national public health survey. The median follow-up time to death and re-hospitalization was 835 (interquartile range, 390-1,432) and 157 (43-583) days, respectively. Associations between baseline reported physical activity, mortality and re-hospitalization risk were analyzed using multivariable Cox regression analysis. Plasma samples from 295 study participants were analyzed with a proximity extension assay consisting of 92 proteins. Associations between proteins and physical activity were explored using a false discovery rate of <5%, and significant associations were taken forward to multivariate analyses. ResultsIn the multivariate Cox regression model, physical inactivity, defined as physical activity time <1 h throughout the week was associated with increased risk of all-cause mortality (HR 1.71; CI95% 1.26-2.31; p = 5.9 x 10(-4)) as well as all-cause re-hospitalization (HR 1.27; CI95% 1.01-1.60; p = 0.038). Further, physical inactivity was associated with elevated plasma levels of Metalloproteinase inhibitor 4, Soluble interleukin 1 receptor-like 1, Elafin and Transferrin receptor protein 1, which are implicated in myocardial fibrosis, migration and apoptosis. ConclusionsSelf-reported low weekly physical activity is associated with increased risk of mortality and re-hospitalization in patients hospitalized for HF independent of traditional risk factors. Furthermore, physical inactivity was associated with elevated levels of 4 proteins linked to cardiovascular disease.

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