Malmö University Publications
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  • 1.
    Cárdenas, Marité
    et al.
    Malmö University, Faculty of Health and Society (HS), Department of Biomedical Science (BMV). Malmö University, Biofilms Research Center for Biointerfaces. Univ Basque Country & Consejo Super Invest Cient, Biofis Inst, UPV EHU CSIC, Leioa 48940, Spain.;Basque Fdn Sci, IKERBASQUE, Bilbao, Spain..
    Campbell, Richard A.
    Univ Manchester, Fac Biol Med & Hlth, Div Pharm & Optometry, Manchester M13 9PT, England..
    Arteta, Marianna Yanez
    AstraZeneca, Adv Drug Delivery Pharmaceut Sci, R&D, S-43183 Gothenburg, Sweden..
    Lawrence, M. Jayne
    Univ Manchester, Fac Biol Med & Hlth, Div Pharm & Optometry, Manchester M13 9PT, England..
    Sebastiani, Federica
    Politecn Milan, Dept Chem Mat & Chem Engn, I-20131 Milan, Italy.;Lund Univ, Dept Chem, Div Phys Chem, S-22100 Lund, Sweden..
    Review of structural design guiding the development of lipid nanoparticles for nucleic acid delivery2023In: Current Opinion in Colloid & Interface Science, ISSN 1359-0294, E-ISSN 1879-0399, Vol. 66, article id 101705Article, review/survey (Refereed)
    Abstract [en]

    Lipid nanoparticles (LNPs) are the most versatile and successful gene delivery systems, notably highlighted by their use in vaccines against COVID-19. LNPs have a well-defined core-shell structure, each region with its own distinctive compositions, suited for a wide range of in vivo delivery applications. Here, we discuss how a detailed knowledge of LNP structure can guide LNP formulation to improve the efficiency of delivery of their nucleic acid payload. Perspectives are detailed on how LNP structural design can guide more efficient nucleic acid transfection. Views on key physical characterization techniques needed for such developments are outlined including opinions on biophysical approaches both correlating structure with functionality in biological fluids and improving their ability to escape the endosome and deliver they payload.

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  • 2.
    Kocherbitov, Vitaly
    Malmö högskola, Faculty of Health and Society (HS), Department of Biomedical Science (BMV).
    Application of scanning methods to distinguish between entropy and enthalpy driven phase transitions2013In: Current Opinion in Colloid & Interface Science, ISSN 1359-0294, E-ISSN 1879-0399, Vol. 18, no 6, p. 510-516Article, review/survey (Refereed)
    Abstract [en]

    All phase transitions can be divided into enthalpy and entropy driven. The driving forces of phase transitions in aqueous soft matter systems can be resolved by applying scanning methods. In this review three experimental methods — sorption calorimetry, differential scanning calorimetry and humidity scanning quartz crystal microbalance with dissipation monitoring are described. Advantages and disadvantages of the methods are discussed. The driving forces of phase transitions can be directly measured using sorption calorimetry or calculated using van der Waals differential equation using experimental data obtained by other methods. The results of experimental studies show that in surfactant and lipid systems the phase transitions to phases with higher curvature are driven by enthalpy, while phase transitions to phases with lower curvature are driven by entropy.

  • 3.
    Sparr, Emma
    et al.
    Lund Univ, Div Phys Chem, POB 124, S-22100 Lund, Sweden..
    Björklund, Sebastian
    Malmö University, Faculty of Health and Society (HS), Department of Biomedical Science (BMV). Malmö University, Biofilms Research Center for Biointerfaces.
    Pham, Q. Dat
    Lund Univ, Div Phys Chem, POB 124, S-22100 Lund, Sweden.;Gillette Reading Innovat Ctr, Reading RG2 0QE, Berks, England..
    Mojumdar, Enamul H.
    Lund Univ, Div Phys Chem, POB 124, S-22100 Lund, Sweden.;CR Competence AB, Box 124, S-22100 Lund, Sweden..
    Stenqvist, B.
    Lund Univ, Div Phys Chem, POB 124, S-22100 Lund, Sweden..
    Gunnarsson, M.
    Lund Univ, Div Phys Chem, POB 124, S-22100 Lund, Sweden.;Wellspect HealthCare, Aminogatan 1, S-43153 Mölndal, Sweden..
    Topgaard, D.
    Lund Univ, Div Phys Chem, POB 124, S-22100 Lund, Sweden..
    The stratum corneum barrier - From molecular scale to macroscopic properties2023In: Current Opinion in Colloid & Interface Science, ISSN 1359-0294, E-ISSN 1879-0399, Vol. 67, article id 101725Article, review/survey (Refereed)
    Abstract [en]

    The upper layer of our skin, the stratum corneum (SC), is a versatile material that combines mechanical strength with efficient barrier function. In this paper, we discuss these macroscopic properties of SC in relation to recent findings on molecular responses and structural diversity in SC protein and lipids. We put particular focus on the intermediate (colloidal) length scale and how the different SC substructures are organized with respect to each other, including effects of nonequilibrium conditions in the skin with respect to the gradients in water and other components.

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  • 4.
    Svensson, Olof
    et al.
    Malmö högskola, Faculty of Health and Society (HS).
    Arnebrant, Thomas
    Malmö högskola, Faculty of Health and Society (HS).
    Mucin layers and multilayers — Physicochemical properties and applications2010In: Current Opinion in Colloid & Interface Science, ISSN 1359-0294, E-ISSN 1879-0399, Vol. 15, no 6, p. 395-405Article, review/survey (Other academic)
    Abstract [en]

    The present review summarizes recent, and important previous, findings on properties of mucin layers and multilayers and ways to tailor their properties. Specifically, progress has been made in understanding the effects of mucin type, preparations, ambient conditions and surface properties on adsorption and on mixed layer assembly including multilayers. Apart from structural features the stability, lubrication and biological functions of such layers are addressed.

  • 5. Valldeperas, Maria
    et al.
    Salis, Andrea
    Barauskas, Justas
    Tiberg, Fredrik
    Arnebrant, Thomas
    Malmö University, Faculty of Health and Society (HS), Department of Biomedical Science (BMV).
    Razumas, Valdemaras
    Monduzzi, Maura
    Nylandert, Tommy
    Enzyme encapsulation in nanostructured self-assembled structures: Toward biofunctional supramolecular assemblies2019In: Current Opinion in Colloid & Interface Science, ISSN 1359-0294, E-ISSN 1879-0399, Vol. 44, p. 130-142Article, review/survey (Refereed)
    Abstract [en]

    Enzymes have come into use for many new applications outside their natural biological environment, taking advantage of their high efficiency and selectivity as biocatalysts. Such new application often requires encapsulation to preserve the structure and activity of the enzyme, but also to regulate and control the activity. Here, we will discuss two types of encapsulation, soft matrices consisting of polar lipid liquid crystals and hard ordered mesoporous silica matrices. For both types of matrices, the challenge is to control the pore size of the matrices and the interaction with the matrix interface. Here, the polar lipid liquid crystals offer larger flexibility than silica, but on the other hand, it is considerably more sensitive to the environment.

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