In this paper we present a feature descriptor, based on a Markov random field (MRF) texture model, for radio-frequency (RF) ultrasound data. The proposed approach combines global data statistics in terms of a maximum-likelihood-estimated (MLE) distribution with local pattern characteristics employing MRF interaction parameters. This combining approach facilitates the encoding of the underlying nature of the ultrasound envelope data and therefore represents a powerful feature descriptor. Applicability and performance is showcased on RF data from a human neck.