All devices are recognized as foreign body materials once inserted in the living body, and they will all cause foreign body reactions. To determine the degree of integration, both qualitative and quantitative data are obtained by examining histological sections. This technique is the state of the art and has been so for decades. Quantitative analysis is important, but one cannot solely rely on data that computer programs rather rapidly generate. The qualitative examinations are of utmost importance. Tissue which has been properly fixed, processed, and maintained in the laboratories can be used for a broad range of histological analysis. This chapter presents some qualitative and quantitative state-of-the-art techniques used in relation to bone tissue analyses around biomaterials. Methods are described from fixation of tissue, preparation of sections, routine and new techniques adjusted to state-of-the-art techniques, and some complementary techniques. The importance of investigating the tissue reactions in various levels, from light microscopic to molecular, such as the localization of proteins as well as some quantification methods will be presented. In the future, we foresee even more complementary techniques to obtain more information regarding this tissue.