In recent decades, research on the knowledge of indigenous cultures has gained more and more recognition in the field of science and technology education. Indigenous knowledge was promoted in terms of justice for indigenous peoples, respect for values and indigenous knowledge, the potential for intercultural learning, and chances for supporting education for sustainability. Various efforts have been made by both indigenous and non-indigenous scholars to introduce indigenous knowledge into science and technology curricula. In this chapter, we explore concepts and recent studies on indigenous knowledge in science and technology education, with important questions related to the topic.