Since the 2011 Syrian civil war, the Middle East regional security complex have been witnessing increasingly intense security interdependence. The conflict has turned into a regional proxy war where regional actors are competing for regional influence. Assad was initially securitized by regional actors but these same actors are currently trying to desecuritize and normalize relations with him. This paper aims at studying the security factors behind the recent regional normalization with Assad and the possible obstacles. Buzan and Weaver’s regional security complex theory is used in a qualitative case study to analyze the penetration by global powers along with regional threats and regional securitization/desecuritization patterns. The analysis shows the impact of US disengagement coupled with the Chinese and Russian penetration on changing the regional security structure. Similarly, the usage of proxies and drug trafficking have had major regional security consequences. Lastly, the desecuritization/normalization process is securitized by both state and non-state actors.