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Periodontitis Impact on Inflammatory Bowel Disease Activity: A Survey in a Swedish Cohort of IBD Patients
Malmö University, Faculty of Odontology (OD).
Malmö University, Faculty of Odontology (OD).
2023 (English)Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

Aim: The present study investigated whether presence of self-reported periodontitis and tooth loss have an impact on inflammatory bowel disease (IBD) (i.e., severity and/or activity) in a Swedish patient cohort.  

Materials and Methods: An internet-based survey with questions on social demographics, oral health (e.g., indicating presence of severe periodontitis) and IBD characteristics based on validated disease indices was sent to the members of the Swedish Colitis-Chron patient association.   

Results: The survey was answered by 371 patients with Crohn´s disease and 415 with ulcerative colitis. 302 patients were classified with severe periodontitis and 150 patients reported less than 20 remaining teeth. IBD patients reporting a reduced number of teeth (coefficient 4.47; 95% CI, 0.71–8.22; p = 0.020) and severe periodontitis (coefficient 5.07; 95% CI, 1.86–8.28; p = 0.002) were associated with a higher IBD-disability score. Furthermore, self-reported severe periodontitis was associated with higher disease activity in the last 12 months (OR 1.44; 95% CI: 1.05; 1.99; p = 0.025) and with higher odds for current disease activity (OR 1.72; 95% CI: 1.19; 2.49; p = 0.004). IBD severity defined by history of surgery due to IBD and/or intake of biological medications showed no association.    

Conclusion: Based on the data of the current study it can be concluded that self-reported periodontitis and tooth loss are significantly associated with increased self-reported IBD-related disability and more IBD activity. These results emphasise that oral health of IBD patients should be monitored closely and any problems should be treated accordingly. Finally, they highlight the need for further longitudinal investigations of the relationship between oral health and IBD.   

Abstract [sv]

Syfte: Studien har i en svensk patientgrupp undersökt om självrapporterad parodontit och tandförlust har en påverkan på inflammatorisk tarmsjukdom (IBD) (dvs. allvarlighetsgrad och/eller aktivitet).

Material och metod: En internetbaserad enkätundersökning med frågor om social demografi, oral hälsa (t.ex. indikering på förekomst av svår parodontit) och karaktär på IBD, baserade på validerade sjukdomsindex, skickades ut till medlemmar i det svenska Mag- och tarmförbundet. 

Resultat: Enkäten besvarades av 371 patienter med Crohns sjukdom och 415 med ulcerös kolit. 302 IBD patienter klassificerades med svår parodontit och 150 rapporterade mindre än 20 kvarvarande tänder. IBD patienter som rapporterade ett reducerat antal kvarvarande tänder (coefficient 4.47; 95% CI, 0.71-8.22; p = 0.020) och svår parodontit (coefficient 5.07; 95% CI, 1.86-8.28; p = 0.002) kunde associeras med en högre IBD disability score. Självrapporterad svår parodontit var associerad med en högre sjukdomsaktivitet de senaste 12 månaderna (OR 1.44; 95% CI: 1.05; 1.99; p = 0.025) och hade högre odds för nuvarande sjukdomsaktivitet (OR 1.72; 95% CI 1.19; 2.49; p = 0.004). IBD sjukdomens svårighetsgrad, definierad av historik av kirurgi och/eller medicinering med biologiska läkemedel visade ingen association. 

Slutsats: Baserat på data från denna studie, kan slutsatsen dras att självrapporterad parodontit och tandförlust är signifikant associerade med ökad självrapporterad IBD relaterad funktionsnedsättning och mer IBD aktivitet. Dessa resultat betonar att oral hälsa hos IBD patienter bör övervakas noggrant och problem följaktligen behandlas. Resultaten belyser också behovet av vidare longitudinella undersökningar kring relationen mellan oral hälsa och IBD. 

Place, publisher, year, edition, pages
2023. , p. 33
Keywords [en]
Periodontitis, IBD, Disease activity, PESS, survey, epidemiology
Keywords [sv]
Parodontit, IBD, Sjukdomsaktivitet, PESS, enkät, epidemiologi
National Category
Dentistry
Identifiers
URN: urn:nbn:se:mau:diva-60138OAI: oai:DiVA.org:mau-60138DiVA, id: diva2:1763574
External cooperation
Mag- & Tarmförbundet
Educational program
OD Tandläkarutbildning
Supervisors
Examiners
Available from: 2023-06-29 Created: 2023-06-07 Last updated: 2023-06-29Bibliographically approved

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