Compared to Anglo-American instructional design, European Didaktik has focused much more on content and relevance. This presentation is based on concepts such as disciplinary literacy, powerful knowledge, Bildung, sustainability education and didaktik models (Sjöström, 2019; Sjöström, Eilks & Talanquer, 2020), as well as on their interrelationships. Recent ideas of didaktik models supporting eco-reflexive Bildung (Herranen et al., 2021), ChemoKnowings (Herranen et al., 2021; Yavuzkaya et al., 2022) and chemical agency (Yavuzkaya et al., 2022) will be presented and discussed. Eco-reflexive Bildung-oriented chemistry/science education should, in addition to (a) transformative subject knowledge, emphasize both (b) scientific processes – NOS (Nature of Science) – and (c) societal contexts – STSE (Science-Technology-Society-Environment) (Sjöström, Eilks & Zuin, 2016). In practice, this would mean including more philosophical, ethical and socio-political perspectives in chemistry/science education, and the focus should be on meaningfulness, problematization, understanding uncertainties and balancing the benefits and risks of science and technology.