The social worker-client relationship is described as essential to social work but is a broad and multi-layered concept. Today, the relationship is strengthened and challenged by digitalisation. The aim of this configurative literature review is to understand how research on social work from 2015 to 2020 describes and analyses digitalisation’s significance for the social worker-client relationship. Three themes depict the benefits and disadvantages of digitalisation, how digitalisation generates new ethical questions and dilemmas, and the different theoretical perspectives used. Future research should go beyond the pros and cons of digitalisation and should use various theoretical approaches to challenge data, illuminate client perspectives, and pose additional questions.