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Sensory recovery and oral health-related quality of life following tongue reconstruction using non-innervated radial forearm free flaps
Department of Stomatology, The Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Health, Hangzhou 310052, China; Orofacial Pain & TMD Research Unit, Institute of Stomatology, Affiliated Hospital of Stomatology, Nanjing Medical University, 136 Hanzhong Road, Nanjing 210029, China.
Orofacial Pain & TMD Research Unit, Institute of Stomatology, Affiliated Hospital of Stomatology, Nanjing Medical University, 136 Hanzhong Road, Nanjing 210029, China.
Department of Stomatology, The Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Health, Hangzhou 310052, China; Department of Orthodontics, Institute of Stomatology, Affiliated Hospital of Stomatology, Nanjing Medical University, 136 Hanzhong Road, Nanjing 210029, China.
Malmö University, Faculty of Odontology (OD). Orofacial Pain & TMD Research Unit, Institute of Stomatology, Affiliated Hospital of Stomatology, Nanjing Medical University, 136 Hanzhong Road, Nanjing 210029, China; Section for Orofacial Pain and Jaw Function, School of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark; Scandinavian Center for Orofacial Neurosciences (SCON), Sweden.ORCID iD: 0000-0001-5809-8037
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2021 (English)In: Oral Oncology, ISSN 1368-8375, E-ISSN 1879-0593, Vol. 121, article id 105471Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES: This study aimed to monitor the recovery of somatosensory function and oral health-related quality of life after tongue reconstruction using a non-innervated radial forearm free flap (RFFF).

METHODS: Twenty patients (9 men, age: 42-67 years) underwent tongue reconstruction with non-innervated RFFFs, and twenty age- and sex-matched controls were included in this study. Quantitative sensory testing (QST), including cold, warm, and mechanical detection thresholds (CDT, WDT, MDT); cold, heat, and mechanical pain thresholds (CPT, HPT, MPT); and static two-point, sharp/blunt, and direction discrimination (S2-PD, S/BD, DD) were determined 9 months and 18 months after surgery on the surgical (9 M, 18 M) and contralateral sides (9Mc, 18Mc). Oral Health Impact Profile-49 (OHIP-49) was used to determine the oral-related quality of life of participants.

RESULTS: All parameters showed significantly lower sensitivity at 9 M and 18 M (p < 0.001) compared to those for the controls and the contralateral side, except for DD (p = 0.101). In addition, the parameters showed a significant decrease in sensitivity for 9Mc and 18Mc (p ≤ 0.043) compared to those for the controls, except for MPT, HPT, S/SD, and DD (p ≥ 0.453). Findings on WDT, MPT, S2-PD, and DD (p ≤ 0.046) indicated significantly higher somatosensory function at 18 M than that at 9 M. MDT and MPT (p ≤ 0.038) showed significantly higher sensitivity at 18Mc than at 9Mc. Scores for all dimensions of OHIP-49 were significantly higher in patients (decrease in quality of life, p ≤ 0.002) than in controls, except for physical discomfort (p = 0.51). However, the scores were significantly higher at 18 M than at 9 M (p ≤ 0.011), except for handicap (p = 0.36). Postoperative chemotherapy was significantly correlated with impaired thermal sensitivity of the flaps (WDT, p = 0.049).

CONCLUSION: The present findings showed significant impairment in somatosensory function on both the surgical and contralateral sides of patients with RFFFs. However, a significant increase in somatosensory function was observed on both sides over time. Somatosensory disturbances observed after surgery were associated with poor oral health-related quality of life.

Place, publisher, year, edition, pages
Elsevier, 2021. Vol. 121, article id 105471
Keywords [en]
Hemiglossectomy, Non-innervated radial forearm free flap, Oral Health Impact Profile, Quantitative sensory testing, Sensory recovery, Tongue reconstruction
National Category
Dentistry
Identifiers
URN: urn:nbn:se:mau:diva-45000DOI: 10.1016/j.oraloncology.2021.105471ISI: 000697001900011PubMedID: 34352555Scopus ID: 2-s2.0-85111560522OAI: oai:DiVA.org:mau-45000DiVA, id: diva2:1586469
Available from: 2021-08-20 Created: 2021-08-20 Last updated: 2024-02-05Bibliographically approved

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