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The Protein Corona Leads to Deformation of Spherical Micelles
Centre for Advanced Macromolecular Design, School of Chemistry, The University of New South Wales, Sydney, 2052, Australia.
Centre for Advanced Macromolecular Design, School of Chemistry, The University of New South Wales, Sydney, 2052, Australia.
Centre for Advanced Macromolecular Design, School of Chemistry, The University of New South Wales, Sydney, 2052, Australia.
Centre for Advanced Macromolecular Design, School of Chemistry, The University of New South Wales, Sydney, 2052, Australia.
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2021 (English)In: Angewandte Chemie International Edition, ISSN 1433-7851, E-ISSN 1521-3773, Vol. 60, no 18, p. 10342-10349Article in journal (Refereed) Published
Abstract [en]

The formation of a non-specific protein corona around nanoparticles (NPs) has been identified as one of the culprits for failed nanomedicine. The amount and type of adsorbed protein from the blood plasma are known to determine the fate of NPs and the accessibility of targeting ligands. Herein, we show that the adsorbed protein may not only enlarge the NPs and change their surface properties but also, in the case of soft NPs such as polymer micelles, lead to deformation. Poly(1-O-methacryloyl -beta-D-fructopyranose)-b-poly(methylmethacrylate) (P(1-O-MAFru)-b-PMMA) block co-polymers were self-assembled into NPs with a spherical core-shell morphology as determined by small angle neutron scattering (SANS). Upon incubation with albumin, TEM, SANS, and small angle X-ray scattering (SAXS) revealed the adsorption of albumin and deformation of the NPs with a spheroid geometry. Removal of the protein led to the reversal of the morphology back to the spherical core-shell structure. Structural studies and cell studies of uptake of the NPs imply that the observed deformation may influence blood circulation time and cell uptake.

Place, publisher, year, edition, pages
John Wiley & Sons, 2021. Vol. 60, no 18, p. 10342-10349
Keywords [en]
drug delivery, glycopolymers, nanoparticles, protein corona, spherical micelles
National Category
Physical Chemistry
Identifiers
URN: urn:nbn:se:mau:diva-41524DOI: 10.1002/anie.202101129ISI: 000631486000001PubMedID: 33543582Scopus ID: 2-s2.0-85103282208OAI: oai:DiVA.org:mau-41524DiVA, id: diva2:1541503
Available from: 2021-04-01 Created: 2021-04-01 Last updated: 2023-10-05Bibliographically approved

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Garvey, Christopher J.

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Garvey, Christopher J.Stenzel, Martina H.
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Department of Biomedical Science (BMV)Biofilms Research Center for Biointerfaces
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