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Enamel matrix derivative in liquid form as adjunct to natural bovine bone grafting at buccal bone dehiscence defects at implant sites: An experimental study in beagle dogs
Malmö University, Faculty of Odontology (OD). Department of Periodontology, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, Tokyo, Japan.ORCID iD: 0000-0001-9862-4281
Department of Periodontology, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, Tokyo, Japan.
Department of Periodontology, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, Tokyo, Japan.
Department of Periodontology, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, Tokyo, Japan.ORCID iD: 0000-0002-1066-7541
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2019 (English)In: Clinical Oral Implants Research, ISSN 0905-7161, E-ISSN 1600-0501, Vol. 30, no 10, p. 989-996Article in journal (Refereed) Published
Abstract [en]

Objectives To evaluate the effect of enamel matrix derivative in liquid form (EMD-liquid) as adjunct to grafting with natural bovine bone (NBB), on new bone formation and osseointegration in buccal dehiscence defects at dental implants. Material and methods In six beagles, 3 months after extraction of the mandibular premolars and first molars. Three titanium implants (3.3 o x 8.0 mm) were inserted, and dehiscence-type defects (mesiodistal width 3 mm x 5 mm depth) were created on their buccal aspect. The defects were randomly assigned to one of the following three treatment groups: Group 1: NBB, Group 2: NBB/EMD-L, Group 3: Control. All sites were covered with a collagen membrane. Histomorphometric measurements were performed after 3 months of healing. Results New bone area, bone-to-implant contact (BIC), and first BIC (fBIC) in the NBB and NBB/EMD-L groups were significantly greater than in the control group (p < .05). Further, f-BIC was at a significantly more coronal position in the NBB + EMD-liquid group (0.4 +/- 0.1 mm) compared with the NBB group (1.2 +/- 0.2 mm). Conclusions Natural bovine bone grafting enhances bone regeneration and osseointegration at implants with buccal bone dehiscences compared with no grafting, and adjunct use of EMD-liquid appears to further enhance bone formation and osseointegration.

Place, publisher, year, edition, pages
John Wiley & Sons, 2019. Vol. 30, no 10, p. 989-996
Keywords [en]
alveolar ridge augmentation, dehiscence, dental implant, dogs, enamel matrix proteins, osteogenesis, regeneration
National Category
Dentistry
Identifiers
URN: urn:nbn:se:mau:diva-39182DOI: 10.1111/clr.13512ISI: 000481289900001PubMedID: 31319440Scopus ID: 2-s2.0-85070747525OAI: oai:DiVA.org:mau-39182DiVA, id: diva2:1518129
Available from: 2021-01-15 Created: 2021-01-15 Last updated: 2024-06-17Bibliographically approved

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Ikawa, TakahiroStavropoulos, Andreas

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