The aim of the study was to investigate how professionals attitudes towards psychiatric comorbidity with substance use disorder are portrayed in scientific articles and whether these attitudes are understandable based on the process of stigmatization. Through a systematic literature study, eleven articles was selected to answer the study's purpose. The articles have been reviewed according to a template designed for studies with qualitative methodology. The result of the study was that professionals attitudes towards individuals with comorbidity are shared. In a few articles, it was found that professionals hold positive attitudes towards the group and see it as part of the social work. On the other hand, there was a majority of the professionals who held negative and stigmatizing attitudes by stamping individuals with degrading concepts and actions, which affected the individual in the long run in form of discrimination. The negative attitudes that professionals held against individuals with comorbidity can be linked to the stigmatization process according to Goffman (2011) and Link et al. (2001).