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LITTERATURSTUDIE SAMMANSTÄLLNING AV STUDIER FÖR EFFEKTIVAST BEHANDLINGSALTERNATIV VID GENITAL CANDIDAINFEKTION
Malmö University, Faculty of Health and Society (HS).
2019 (Swedish)Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
Abstract [sv]

Bakgrund: Svampinfektion i underlivet drabbar oftast kvinnor vid fertila ålder, ungefär 75% av kvinnor får det någon gång i livet. Svampinfektioner behandlas med antimykotika framförallt receptfria läkemedel, problemet med frekvent användning av receptfria läkemedel är att svampen kommer tillbaka inom kort igen eller förorsakar att det blir svårare att bli av med svampen. Syftet med studien är att sammanfatta och värdera kvalitén av de tillgängliga randomiserade kontrollerade studier samt avgöra om oral eller lokal antimykotika behandling är effektivast vid genital candidainfektion? Metod: Databassökning av studier genomfördes i både Pubmed och Cochrane Library för att söka efter systematiska reviews, reviews och RCT studier. RCT studierna värderades med CONSORTstatement och bedömdes antingen med låg, medel eller hög kvalité. Studierna sammanställdes i tabeller för att jämföra skillnaden i effektiviteten mellan oral eller lokal behandling. Resultat: Sökningen identifierade 190 studier varav fyra betraktades som relevanta. Bedömningen presenterade en av studierna som hög kvalité och resten medelkvalité. Tre av fyra studier visade ingen skillnad på effektiviteten mellan oral och lokal antimykotika behandling, medan endast en studie visade signifikant skillnad som gynnade den orala behandlingen. Slutsats: Generellt erhöll studier som var inkluderade i denna litteraturstudie bra kvalité vid bedömningen. Dessutom visade majoriteten av undersökningarna från både gamla och nya studier att det inte finns någon skillnad i effektivitet hos orala och intravaginala antimykotika behandling.

Abstract [en]

Background: Vaginal yeast infections usually affect women at fertile age, about 75% of women get it at some point in their lives. Vaginal yeast infections are treated with antimycotics, primarily with non-prescription drugs, the issue with frequent use of non-prescription drugs is that the fungus comes back shortly again, or it becomes difficult to get rid of. The aim of the study is to summarize and evaluate the quality of available randomized controlled trials and determine if oral or local antimycotics treatment is effective in genital candidiasis? Method: Database search of studies was conducted in both PubMed and Cochrane Library to search for systematic reviews, reviews, and RCT studies. RCT studies were evaluated with CONSORT statement and assessed with low, medium or high quality. The studies were compiled in tables to compare the difference in efficacy between oral or local treatment. Result: The search identified 190 studies, of which four were considered relevant. The assessment presented one of the studies as high quality and the rest medium quality. Three out of four studies showed no difference in efficacy between oral and local antifungal therapy, while only one study showed significant difference, which favored the oral treatment. Conclusion: Overall, studies that were included in this literature study were of good quality when assessing. Moreover, most of the researches from both old and new studies showed that there is no difference in the efficacy of oral and intravaginal antifungal therapy.

Place, publisher, year, edition, pages
Malmö universitet/Hälsa och samhälle , 2019. , p. 24
Keywords [sv]
vulvovaginal candidiasis, oral treatment, oral treatment, antimycotic
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:mau:diva-24568Local ID: 28686OAI: oai:DiVA.org:mau-24568DiVA, id: diva2:1485988
Educational program
HS Receptarieprogrammet
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Available from: 2020-11-02 Created: 2020-11-02Bibliographically approved

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Citation style
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