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Design and Characterization of Ethosomes for Transdermal Delivery of Caffeic Acid.
Malmö University, Faculty of Health and Society (HS), Department of Biomedical Science (BMV). Malmö University, Biofilms Research Center for Biointerfaces. Department of Chemical and Pharmaceutical Sciences, University of Ferrara, I-44121 Ferrara, Italy.
Department of Chemical and Pharmaceutical Sciences, University of Ferrara, I-44121 Ferrara, Italy.
Department of Life and Environmental Sciences, Polytechnic University of Marche, I-60131 Ancona, Italy.
Department of Chemical and Pharmaceutical Sciences, University of Ferrara, I-44121 Ferrara, Italy.
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2020 (English)In: Pharmaceutics, ISSN 1999-4923, E-ISSN 1999-4923, Vol. 12, no 8, article id E740Article in journal (Refereed) Published
Abstract [en]

in ethosome after six months, while in water, an almost complete degradation occurred within one month. The addition of poloxamer slightly modified vesicle structure and size, while it decreased the vesicle deformability. Caffeic acid diffusion coefficients from ethosome and ethosome gel were, respectively, 137- and 33-fold lower with respect to the aqueous solution. At last, the caffeic acid permeation and antioxidant power of ethosome were more intense with respect to the simple solution.

Place, publisher, year, edition, pages
MDPI, 2020. Vol. 12, no 8, article id E740
Keywords [en]
caffeic acid, ethosome, in vitro diffusion, oxygen electrode, penetration enhancers
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
URN: urn:nbn:se:mau:diva-18007DOI: 10.3390/pharmaceutics12080740ISI: 000564079300001PubMedID: 32781717Scopus ID: 2-s2.0-85090641048OAI: oai:DiVA.org:mau-18007DiVA, id: diva2:1458637
Available from: 2020-08-17 Created: 2020-08-17 Last updated: 2024-06-17Bibliographically approved

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Ruzgas, Tautgirdas

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