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The long-term effect of a zinc acetate and chlorhexidine diacetate containing mouth rinse on intra-oral halitosis-A randomized clinical trial.
School for Health and Society, Kristianstad University, Kristianstad, Sweden.ORCID iD: 0000-0002-5755-3998
School for Health and Society, Kristianstad University, Kristianstad, Sweden.
School for Health and Society, Kristianstad University, Kristianstad, Sweden; Department of Periodontics, School of Dentistry, University of Washington, Seattle, WA, USA.
School for Health and Society, Kristianstad University, Kristianstad, Sweden; School of Dental Science, Trinity College, Dublin, Ireland; Blekinge Institute of Technology, Karlskrona, Sweden..
2017 (English)In: Journal of Clinical Periodontology, ISSN 0303-6979, E-ISSN 1600-051X, Vol. 44, no 10, p. 1010-1019Article in journal (Refereed) Published
Abstract [en]

AIM: To evaluate the long-term effects of a zinc acetate and chlorhexidine diacetate mouth rinse (Zn/CHX) on intra-oral halitosis.

MATERIALS AND METHODS: Forty-six adults with intra-oral halitosis were randomized into a 6-month, double-blind, placebo-controlled clinical study. The presence of intra-oral halitosis was evaluated at baseline, 3 and 6 months after treatment by assessment of organoleptic score (OLS) and by total volatile sulphur compounds (T-VSC), hydrogen sulphide (H2 S) and methyl mercaptan (MM) concentrations in exhaled air.

RESULTS: A Zn/CHX mouth rinse provided significantly better control of intra-oral halitosis than a placebo mouth rinse. At 3 and 6 months, individuals rinsing with the Zn/CHX rinse presented with reductions of the OLS, T-VSC (p < .01, respectively), H2 S (p < .001), and MM (p < .01) in subjects' exhaled air. At 6 months, 68.2% of individuals using the Zn/CHX rinse experienced a 1 or 2 category improvement in OLS compared with 19.1% of placebo-treated subjects. 91% of subjects in the Zn/CHX group were categorized as being effectively treated for intra-oral halitosis (i.e. H2 S < 112 ppb), compared to 43% in the placebo group.

CONCLUSION: Zn/CHX mouth rinse provides effective long-term efficacy against intra-oral halitosis, assessed both objectively and subjectively. With regular rinsing, the effect was sustained for 6 months.

Place, publisher, year, edition, pages
John Wiley & Sons, 2017. Vol. 44, no 10, p. 1010-1019
Keywords [en]
Zn/CHX rinse, bad breath, halitosis, hydrogen sulphide, mouth rinse, volatile sulphur compounds
National Category
Dentistry
Identifiers
URN: urn:nbn:se:mau:diva-17811DOI: 10.1111/jcpe.12779ISI: 000417407300007PubMedID: 28727160Scopus ID: 2-s2.0-85030086059OAI: oai:DiVA.org:mau-17811DiVA, id: diva2:1454431
Available from: 2020-07-16 Created: 2020-07-16 Last updated: 2023-07-05Bibliographically approved
In thesis
1. Treatment of intra-oral halitosis
Open this publication in new window or tab >>Treatment of intra-oral halitosis
2017 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Intra -oral halitosis (bad breath) is reported to affect 15 -83 % of the adult population. Having intra- oral halitosis is a social and psycho- logical handicap, and may cause people in the person’s social circle to increase the physical distance or to turn their faces in another di- rection to avoid the unpleasant smell from the exhaled air. Such be- haviours may affect the individual’s self -confidence resulting in ins e- curity in social and inti mate relations. The oral health -related quality of life status has also been reported to be lower in individuals with halitosis. Approximately 90% of what is considered as bad breath is the result of the degradation of organic substrates (proteins) by an- aerobic bacteria of the oral cavity. Intra -oral halitosis can be as- sessed using both subjective and objective methods to evaluate the subject’s exhaled air. The most common one and the one often r e- ferred to as the ” gold standard”, is the organoleptic scoring system (OLS). OLS is a subjective method evaluating the strength of halit o- sis in exhaled air using a scale from 0- 5. One objective method to assess the presence of volatile sulphur compounds in exhaled air is to use a sulphide monitor measuring the total sum of the volatile sul- phur compounds (T -VSC) in exhaled air. The three gases (hydrogen sulphide (H 2 S), methyl mercaptan (MM) and dimethyl sulphide (DMS)) in exhaled air related to intra- oral halitosis can be assessed separately using a simplified gas chromatograph. Different treatment models such as periodontal treatment, tongue scraping and rinsing with Zn ion containing products have been used to reduce intra -oral halitosis. The present thesis has evaluated the efficacy of different treatment models in t he treatment of intra -oral halitosis.

Place, publisher, year, edition, pages
Malmö university. Faculty of Odontology, 2017
Series
Doctoral Dissertation in Odontology
Keywords
Halitosis, Dålig andedräkt, Oral hygiene
National Category
Dentistry
Identifiers
urn:nbn:se:mau:diva-7700 (URN)22073 (Local ID)978-91-7104-718-2 (ISBN)978-91-7104-719-9 (ISBN)22073 (Archive number)22073 (OAI)
Note

Note: The papers are not included in the fulltext online.

Paper IV in dissertation as manuscript.

Available from: 2020-02-28 Created: 2020-02-28 Last updated: 2024-03-16Bibliographically approved

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Erovic Ademovski, Seida

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