Industrial Internet is applicable across a broad industrial spectrum including manufacturing, aviation, road and rail transport, power, oil and gas, healthcare, smart cities and buildings. Some of the major impacts of the Industrial Internet include the development of new and innovative services and products, which in turn also has economic benefits. The purpose of this special issue is to bring together research studies proposing novel techniques, algorithms, models, and solutions to address challenges such as interoperability, security, and privacy associated with Industrial Internet, blockchain and Cyber-physical systems.